Polymorphisms in the GNB3 and ADD1 genes and blood pressure in a Chinese population

Shufeng Chen, Hongwei Wang, Xiangfeng Lu, De Pei Liu, Jing Chen, Cashell E. Jaquish, Dabeeru C. Rao, James E. Hixson, Tanika N. Kelly, Liping Hou, Laiyuan Wang, Jianfeng Huang, Chung Shiuan Chen, Treva K. Rice, Paul K. Whelton, Jiang He, Dongfeng Gu

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6 Scopus citations


A large proportion of the phenotypic variation in blood pressure (BP) appears to be inherited as a polygenic trait. This study examined the association between 12 single nucleotide polymorphisms (SNPs) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) and adducin 1 alpha (ADD1) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP. A total of 3,142 individuals from 636 families were recruited from rural north China, and 2,746 met the eligibility criteria for analysis. BP measurements were obtained using a random-zero sphygmomanometer. Genetic variants were determined using SNPlex assays on an automated DNA Sequencer. A mixed linear model was used to estimate the association between each SNP and BP level. After Bonferroni correction, marker rs4963516 of the GNB3 gene remained significantly associated with DBP (corrected P values = 0.006, 0.007 and 0.002 for co-dominant, additive, and recessive models, respectively) and MAP (corrected P values = 0.02, 0.049, and 0.005, respectively). Compared to carriers of the major A allele, CC homozygotes had higher mean DBP (75.81 ± 0.62 vs. 73.46 ± 0.25 mmHg, P = 0.0002) and MAP (91.87 ± 0.68 vs. 89.42 ± 0.28 mmHg, P = 0.0004) after adjusting for covariates of age, gender, BMI, study site, and room temperature during BP measurement. In summary, these data support a role for the GNB3 gene in BP regulation in the Chinese population. Future studies aimed at replicating these novel findings are warranted.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalHuman genetics
Issue number2
StatePublished - Aug 2010


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