Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population

P. C. Mann, M. E. Cooper, K. K. Ryckman, B. Comas, J. Gili, S. Crumley, E. N.A. Bream, H. M. Byers, T. Piester, A. Schaefer, P. J. Christine, A. Lawrence, K. L. Schaa, K. J.P. Kelsey, S. K. Berends, A. M. Momany, E. Gadow, V. Cosentino, E. E. Castilla, J. López CameloC. Saleme, L. J. Day, S. K. England, M. L. Marazita, J. M. Dagle, J. C. Murray

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective:To investigate genetic etiologies of preterm birth (PTB) in Argentina through evaluation of single-nucleotide polymorphisms (SNPs) in candidate genes and population genetic admixture.Study Design:Genotyping was performed in 389 families. Maternal, paternal and fetal effects were studied separately. Mitochondrial DNA (mtDNA) was sequenced in 50 males and 50 females. Y-chromosome anthropological markers were evaluated in 50 males.Result:Fetal association with PTB was found in the progesterone receptor (PGR, rs1942836; P=0.004). Maternal association with PTB was found in small conductance calcium activated potassium channel isoform 3 (KCNN3, rs883319; P=0.01). Gestational age associated with PTB in PGR rs1942836 at 32-36 weeks (P=0.0004). MtDNA sequencing determined 88 individuals had Amerindian consistent haplogroups. Two individuals had Amerindian Y-chromosome consistent haplotypes.Conclusion:This study replicates single locus fetal associations with PTB in PGR, maternal association in KCNN3, and demonstrates possible effects for divergent racial admixture on PTB.

Original languageEnglish
Pages (from-to)336-340
Number of pages5
JournalJournal of Perinatology
Volume33
Issue number5
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

Keywords

  • KCNN3
  • genetic admixture
  • genetic association study
  • hispanic
  • prematurity
  • progesterone receptor

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    Mann, P. C., Cooper, M. E., Ryckman, K. K., Comas, B., Gili, J., Crumley, S., Bream, E. N. A., Byers, H. M., Piester, T., Schaefer, A., Christine, P. J., Lawrence, A., Schaa, K. L., Kelsey, K. J. P., Berends, S. K., Momany, A. M., Gadow, E., Cosentino, V., Castilla, E. E., ... Murray, J. C. (2013). Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population. Journal of Perinatology, 33(5), 336-340. https://doi.org/10.1038/jp.2012.118