Polymorphic repeat in AIB1 does not alter breast cancer risk

Christopher A. Haiman, Susan E. Hankinson, Donna Spiegelman, Graham A. Colditz, Walter C. Willett, Frank E. Speizer, Myles Brown, David J. Hunter

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics. These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population.

Original languageEnglish
Pages (from-to)378-385
Number of pages8
JournalBreast Cancer Research
Volume2
Issue number5
DOIs
StatePublished - 2000

Keywords

  • AIB1 polymorphism
  • Breast cancer
  • Genetic susceptibility
  • Molecular epidemiology

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