Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent

Jian Qian; Nathan P. Wiederhold; Thomas Patterson; Hoja Patterson; Cory J. Berkland

doi:10.1021/acsapm.1c01269

Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent

Jian Qian
, Nathan P. Wiederhold
, Thomas Patterson
, Hoja Patterson
, Cory J. Berkland

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.

Original language	English
Pages (from-to)	6034-6039
Number of pages	6
Journal	ACS Applied Polymer Materials
Volume	3
Issue number	12
DOIs	https://doi.org/10.1021/acsapm.1c01269
State	Published - Dec 10 2021

Keywords

antifungal drug
broad-spectrum antifungal effect
polymeric iron chelator
reductive iron assimilation
siderophore

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10.1021/acsapm.1c01269

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title = "Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent",

abstract = "Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.",

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AU - Qian, Jian

AU - Wiederhold, Nathan P.

AU - Patterson, Thomas

AU - Patterson, Hoja

AU - Berkland, Cory J.

N1 - Publisher Copyright: ©

PY - 2021/12/10

Y1 - 2021/12/10

N2 - Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.

AB - Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.

KW - antifungal drug

KW - broad-spectrum antifungal effect

KW - polymeric iron chelator

KW - reductive iron assimilation

KW - siderophore

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JO - ACS Applied Polymer Materials

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ER -

Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent

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