Polymer matrices for oral delivery

R. Z. Greenley, T. M. Brown, J. Garbow, C. E. Vogt, H. Zia, R. L. Rodgers, M. Christie, L. A. Luzzi

Research output: Contribution to journalConference articlepeer-review

8 Scopus citations

Abstract

A laboratory procedure has been devised in which a polypeptide concentrate can be imbibed into a finely divided powder of a crosslinked (insoluble) polyacid resin with subsequent low temperature removal of the solvent (water or alcohol). If proper drug/resin concentrations are maintained, a monomolecular solid solution of the drug should result which may provide improved bioavailability. A number of polypeptide - polyacid resin combinations have been examined but the concept is best illustrated in vitro by insulin imbibed into poly(acrylic acid) which is 5 mol% crosslinked. After two hours in a synthetic gastric environment only about ten percent of the insulin is lost. When the medium is adjusted to conditions found in a synthetic intestinal fluid, a rapid release of insulin occurs.

Original languageEnglish
Pages (from-to)182-183
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
StatePublished - Aug 1 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

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