Abstract
A laboratory procedure has been devised in which a polypeptide concentrate can be imbibed into a finely divided powder of a crosslinked (insoluble) polyacid resin with subsequent low temperature removal of the solvent (water or alcohol). If proper drug/resin concentrations are maintained, a monomolecular solid solution of the drug should result which may provide improved bioavailability. A number of polypeptide - polyacid resin combinations have been examined but the concept is best illustrated in vitro by insulin imbibed into poly(acrylic acid) which is 5 mol% crosslinked. After two hours in a synthetic gastric environment only about ten percent of the insulin is lost. When the medium is adjusted to conditions found in a synthetic intestinal fluid, a rapid release of insulin occurs.
| Original language | English |
|---|---|
| Pages (from-to) | 182-183 |
| Number of pages | 2 |
| Journal | American Chemical Society, Polymer Preprints, Division of Polymer Chemistry |
| Volume | 31 |
| Issue number | 2 |
| State | Published - Aug 1990 |
| Event | Papers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA Duration: Aug 26 1990 → Aug 31 1990 |