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Polyglutamine diseases: Emerging concepts in pathogenesis and therapy
Jieya Shao
, Marc I. Diamond
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Siteman Cancer Center
Section of Molecular Oncology & Developmental Therapeutics
DBBS - Molecular Cell Biology
DBBS - Molecular Genetics and Genomics
DBBS - Biochemistry, Biophysics, and Structural Biology
DBBS - Cancer Biology
Research output
:
Contribution to journal
›
Review article
›
peer-review
232
Scopus citations
Overview
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Keyphrases
Pathogenic Proteins
100%
Polyglutamine Disease
100%
Glutamine
50%
Protein Expression
50%
Protein Misfolding
50%
Protein Aggregation
50%
Conformational Change
50%
Relative Role
50%
Specific Genes
50%
Protein Cleavage
50%
Therapeutic Strategies
50%
Huntington's Disease
50%
Proteolytic Cleavage
50%
Spinocerebellar Ataxia
50%
Metabolic Disturbances
50%
Protein Conformation
50%
Direct Targeting
50%
Neurodegenerative Conditions
50%
Polyglutamine Expansion
50%
Dentatorubral-pallidoluysian Atrophy (DRPLA)
50%
Polyglutamine Proteins
50%
Functional Perturbation
50%
Spinobulbar muscular Atrophy
50%
CAG Triplet Repeat
50%
Triplet Repeat Expansion
50%
Medicine and Dentistry
Polyglutamine
100%
Diseases
100%
Protein Expression
25%
Disease
25%
Water-Electrolyte Imbalance
25%
Glutamine
25%
Huntington's Disease
25%
Protein Misfolding
25%
Protein Cleavage
25%
Target Protein
25%
Protein Conformation
25%
Spinocerebellar Ataxia
25%
Kennedy Disease
25%
Dentatorubral-Pallidoluysian Atrophy
25%
Protein Aggregation
25%
Neuroscience
Polyglutamine
100%
Protein Expression
25%
Protein Misfolding
25%
Protein Aggregation
25%
Protein Cleavage
25%
Huntington's Disease
25%
Spinocerebellar Ataxia
25%
Glutamine
25%
Muscle Atrophy
25%
Metabolic Disorder
25%
Protein Conformation
25%
Dentatorubral-Pallidoluysian Atrophy
25%
Pharmacology, Toxicology and Pharmaceutical Science
Polyglutamine
100%
Diseases
100%
Huntington Chorea
25%
Spinocerebellar Degeneration
25%
Glutamine
25%
Kennedy Disease
25%
Dentatorubropallidoluysian Atrophy
25%
Metabolic Disorder
25%