@article{eb408809030f4dae823f38826c1469c6,
title = "Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in Adolescents and Young Adults",
abstract = "In this project, we aimed to bring large-scale gene-identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders—based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)—predicted externalizing disorders, subclinical externalizing behavior, and impulsivity-related traits among adolescents (n = 248) and young adults (n = 207) and whether parenting and peer factors in adolescence moderated polygenic risk to predict externalizing disorders. Polygenic scores predicted externalizing disorders in adolescents and young adults, even after we controlled for parental externalizing-disorder history. Polygenic scores also predicted subclinical externalizing behavior and impulsivity traits in the adolescents and young adults. Adolescent parental monitoring and peer substance use moderated polygenic scores to predict externalizing disorders. This illustrates how state-of-the-science genetics can be integrated with psychological science to identify how genetic risk contributes to the development of psychopathology.",
keywords = "Collaborative Study on the Genetics of Alcoholism (COGA), developmental, externalizing disorders, gene-by-development, gene-by-environment, impulsivity, polygenic",
author = "Salvatore, {Jessica E.} and Fazil Aliev and Kathleen Bucholz and Arpana Agrawal and Victor Hesselbrock and Michie Hesselbrock and Lance Bauer and Samuel Kuperman and Schuckit, {Marc A.} and Kramer, {John R.} and Edenberg, {Howard J.} and Foroud, {Tatiana M.} and Dick, {Danielle M.}",
note = "Funding Information: This national collaborative study is supported by National Institutes of Health (NIH) Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse. The Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine is partially supported by NCI Cancer Center Support Grant P30 CA91842 to the Siteman Cancer Center and by Institute of Clinical and Translational Sciences/Clinical and Translational Science Award Grant UL1RR024992 from the National Center for Research Resources (NCRR), a component of the NIH, and NIH Roadmap for Medical Research. This work was also supported by Grants K02AA018755 (to D. M. Dick), K02DA032573 (to A. Agrawal), and T32MH20030-14 and F32AA022269 (to J. E. Salvatore). This publication is solely the responsibility of the authors and does not necessarily represent the official views of the NCRR or NIH. Publisher Copyright: {\textcopyright} 2014, {\textcopyright} The Author(s) 2014.",
year = "2015",
month = mar,
day = "1",
doi = "10.1177/2167702614534211",
language = "English",
volume = "3",
pages = "189--201",
journal = "Clinical Psychological Science",
issn = "2167-7026",
number = "2",
}