@article{6666855016d04783914e540ccbac09a1,
title = "Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder",
abstract = "Bipolar disorder is often comorbid with anxiety, which is itself associated with poorer clinical outcomes, including suicide. A better etiologic understanding of this comorbidity could inform diagnosis and treatment. The present study aims to test whether comorbid anxiety in bipolar disorder reflects shared genetic risk factors. We also sought to assess the contribution of genetic risk for anxiety to suicide attempts in bipolar disorder. Polygenic risk scores (PRS) were calculated from published genome-wide association studies of samples of controls and cases with anxiety (n = 83,566) or bipolar disorder (n = 51,710), then scored in independent target samples (total n = 3369) of individuals with bipolar disorder who reported or denied lifetime anxiety disorders or suicidal attempts in research interviews. Participants were recruited from clinical and nonclinical settings and genotyped for common genetic variants. The results show that polygenic risk for anxiety was associated with comorbid anxiety disorders and suicide attempts in bipolar disorder, while polygenic risk for bipolar disorder was not associated with any of these variables. Our findings point out that comorbid anxiety disorders in bipolar disorder reflect a dual burden of bipolar and anxiety-related genes; the latter may also contribute to suicide attempts. Clinical care that recognizes and addresses this dual burden may help improve outcomes in people living with comorbid bipolar and anxiety disorders.",
author = "{Bipolar Genome Study Consortium (BiGS)} and Lopes, {Fabiana L.} and Kevin Zhu and Purves, {Kirstin L.} and Christopher Song and Kwangmi Ahn and Liping Hou and Nirmala Akula and Layla Kassem and Bergen, {Sarah E.} and Mikael Landen and Veras, {Andre B.} and Nardi, {Antonio E.} and Ney Alliey-Rodriguez and Badner, {Judith A.} and Wade Berrettini and William Byerley and William Coryell and Craig, {David W.} and Edenberg, {Howard J.} and Tatiana Foroud and Gershon, {Elliot S.} and Greenwood, {Tiffany A.} and Yiran Guo and Keating, {Brendan J.} and Koller, {Daniel L.} and Lawson, {William B.} and Chunyu Liu and Mahon, {Pamela B.} and McInnis, {Melvin G.} and Murray, {Sarah S.} and Nurnberger, {John L.} and Nwulia, {Evaristus A.} and Panganiban, {Corrie B.} and John Rice and Schork, {Nicholas J.} and Smith, {Erin N.} and Peng Zhang and Sebastian Z{\"o}llner and Goes, {Fernando S.} and Kelsoe, {John R.} and Nievergelt, {Caroline M.} and Potash, {James B.} and Tatyana Shekhtman and Schilling, {Paul D.} and Zandi, {Peter P.} and McMahon, {Francis J.}",
note = "Funding Information: We are greatly thankful to all study participants without whom this research would not have been accomplished. This research was funded by the NIMH Intramural Research Program (ZIAMH002843). The SWEBIC collection was funded by the Broad Institute from a grant from Stanley Medical Research Institute. Weighting files were received from Purves K and Thalia E. This study utilized the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health, Bethesda, MD. ClinicalTrials.gov Identifier NCT00001174. Funding Information: M.L. reports grants from the Swedish Medical Research Council, grants from the Broad Institute, during the conduct of the study; personal fees from Lundbeck pharmaceuticals, outside the submitted work. J.N. reports a grant from Janssen, outside the submitted work. All other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41398-020-00981-5",
language = "English",
volume = "10",
journal = "Translational psychiatry",
issn = "2158-3188",
number = "1",
}