TY - JOUR
T1 - Poly(d-glucose carbonate) block copolymers
T2 - A platform for natural product-based nanomaterials with solvothermatic characteristics
AU - Gustafson, Tiffany P.
AU - Lonnecker, Alexander T.
AU - Heo, Gyu Seong
AU - Zhang, Shiyi
AU - Dove, Andrew P.
AU - Wooley, Karen L.
PY - 2013/9/9
Y1 - 2013/9/9
N2 - A natural product-based polymer platform, having the characteristics of being derived from renewable materials and capable of breaking down, ultimately, into natural byproducts, has been prepared through the ring-opening polymerization (ROP) of a glucose-based bicyclic carbonate monomer. ROP was carried out via chain extension of a polyphosphoester (PPE) macroinitiator in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) organocatalyst to afford the PPE-b-poly(d-glucose carbonate) (PDGC) block copolymer. This new copolymer represents a functional architecture that can be rapidly transformed through thiol-yne reactions along the PPE segment into a diverse variety of amphiphilic polymers, which interestingly display stimuli-sensitive phase behavior in the form of a lower critical solution temperature (LCST). Below the LCST, they undergo self-assembly to form spherical core-shell nanostructures that display a poorly defined core-shell morphology. It is expected that hydrophobic patches are exposed within the micellar corona, reminiscent of the surface complexity of proteins, making these materials of interest for triggered and reversible assembly disassembly processes.
AB - A natural product-based polymer platform, having the characteristics of being derived from renewable materials and capable of breaking down, ultimately, into natural byproducts, has been prepared through the ring-opening polymerization (ROP) of a glucose-based bicyclic carbonate monomer. ROP was carried out via chain extension of a polyphosphoester (PPE) macroinitiator in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) organocatalyst to afford the PPE-b-poly(d-glucose carbonate) (PDGC) block copolymer. This new copolymer represents a functional architecture that can be rapidly transformed through thiol-yne reactions along the PPE segment into a diverse variety of amphiphilic polymers, which interestingly display stimuli-sensitive phase behavior in the form of a lower critical solution temperature (LCST). Below the LCST, they undergo self-assembly to form spherical core-shell nanostructures that display a poorly defined core-shell morphology. It is expected that hydrophobic patches are exposed within the micellar corona, reminiscent of the surface complexity of proteins, making these materials of interest for triggered and reversible assembly disassembly processes.
UR - http://www.scopus.com/inward/record.url?scp=84883780541&partnerID=8YFLogxK
U2 - 10.1021/bm4010832
DO - 10.1021/bm4010832
M3 - Article
C2 - 23957247
AN - SCOPUS:84883780541
SN - 1525-7797
VL - 14
SP - 3346
EP - 3353
JO - Biomacromolecules
JF - Biomacromolecules
IS - 9
ER -