TY - JOUR
T1 - Polarized alloantigen presentation by airway epithelial cells contributes to direct CD8+T cell activation in the airway
AU - Kreisel, Daniel
AU - Lai, Jiaming
AU - Richardson, Steven B.
AU - Ibricevic, Aida
AU - Nava, Ruben G.
AU - Lin, Xue
AU - Li, Wenjun
AU - Kornfeld, Christopher G.
AU - Miller, Mark J.
AU - Brody, Steven L.
AU - Gelman, Andrew E.
AU - Krupnick, Alexander S.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Activated T lymphocytes are abundant in the airway during lung allograft rejection. Based on respiratory viral studies, it is the current paradigm that T cells cannot divide in the airway, and that their accumulation in the lumen of the respiratory tract is the exclusive result of recruitment from other sites, such as mediastinal lymph nodes. Here, we show that CD8+ T cell activation and proliferation can occur in the airway after orthotopic lung transplantation. We also demonstrate that airway epithelium expresses major histocompatibility class I predominantly on the apical surface, both in vitro and in vivo, and initiates CD8+ T cell responses in a polarized fashion, favoring luminal activation. Our data identify a unique site for CD8+T cell activation after lung transplantation, and suggest that attenuating these responses may provide a clinically relevant target.
AB - Activated T lymphocytes are abundant in the airway during lung allograft rejection. Based on respiratory viral studies, it is the current paradigm that T cells cannot divide in the airway, and that their accumulation in the lumen of the respiratory tract is the exclusive result of recruitment from other sites, such as mediastinal lymph nodes. Here, we show that CD8+ T cell activation and proliferation can occur in the airway after orthotopic lung transplantation. We also demonstrate that airway epithelium expresses major histocompatibility class I predominantly on the apical surface, both in vitro and in vivo, and initiates CD8+ T cell responses in a polarized fashion, favoring luminal activation. Our data identify a unique site for CD8+T cell activation after lung transplantation, and suggest that attenuating these responses may provide a clinically relevant target.
KW - Airway epithelium
KW - CD8+ T cell
KW - Lung transplantation
KW - Mouse
UR - http://www.scopus.com/inward/record.url?scp=80051571854&partnerID=8YFLogxK
U2 - 10.1165/rcmb.2010-0099OC
DO - 10.1165/rcmb.2010-0099OC
M3 - Article
C2 - 21653906
AN - SCOPUS:80051571854
SN - 1044-1549
VL - 44
SP - 749
EP - 754
JO - American Journal of Respiratory Cell and Molecular Biology
JF - American Journal of Respiratory Cell and Molecular Biology
IS - 6
ER -