Polarity effects on wound healing using electric stimulation in rabbits

Marybeth Brown, Mary Kate McDonnell, David N. Menton

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33 Scopus citations


The aims of this study were to examine effects of high-voltage stimulation (HVS) on wound closure, tensile properties, and mitotic activity. Thirty-six rabbits were assigned to experimental (n = 18) or control groups. Each animal was anesthetized and a full-thickness incision, 3.5cm long, was made on its back. After 24 hours, experimental rabbits received HVS for two hours, twice daily, for seven days. Polarity was negative the first three days and positive thereafter. Wound closure for HVS treated rabbits was 100%, which was significantly better than that of control rabbits (87%). Tensile strength values and mitotic activity for experimental and control rabbits were comparable. Histologic examination of the wounds suggested a more rapid rate of epithelialization in treated rabbits. Results suggest that electric stimulation, as given, augments wound closure.

Original languageEnglish
Pages (from-to)624-627
Number of pages4
JournalArchives of Physical Medicine and Rehabilitation
Issue number8
StatePublished - Aug 1989


  • Electrotherapy
  • Wound healing


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