Point mutations that boost aromatic amino acid production and CO2 assimilation in plants

Ryo Yokoyama, Marcos V.V. de Oliveira, Yuri Takeda-Kimura, Hirofumi Ishihara, Saleh Alseekh, Stéphanie Arrivault, Vandna Kukshal, Joseph M. Jez, Mark Stitt, Alisdair R. Fernie, Hiroshi A. Maeda

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Aromatic compounds having unusual stability provide high-value chemicals and considerable promise for carbon storage. Terrestrial plants can convert atmospheric CO2 into diverse and abundant aromatic compounds. However, it is unclear how plants control the shikimate pathway that connects the photosynthetic carbon fixation with the biosynthesis of aromatic amino acids, the major precursors of plant aromatic natural products. This study identified suppressor of tyra2 (sota) mutations that deregulate the first step in the plant shikimate pathway by alleviating multiple effector-mediated feedback regulation in Arabidopsis thaliana. The sota mutant plants showed hyper-accumulation of aromatic amino acids accompanied by up to a 30% increase in net CO2 assimilation. The identified mutations can be used to enhance plant-based, sustainable conversion of atmospheric CO2 to high-energy and high-value aromatic compounds.

Original languageEnglish
Article numbereabo3416
JournalScience Advances
Volume8
Issue number23
DOIs
StatePublished - Jun 2022

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