Pocketing the difference: structures of uracil excision repair proteins

Tom Ellenberger

Research output: Contribution to journalShort survey

7 Scopus citations

Abstract

The recognition of abnormal DNA structure by proteins is fundamentally different from sequence-specific DNA binding. Recent crystal structures of uracil-DNA glycosylases show a novel uracil-binding pocket that explains the enzyme's selectivity for uracil-containing DNA and provide a structural basis for exploring the catalytic mechanism of amino-glycosylic bond cleavage.

Original languageEnglish
Pages (from-to)351-354
Number of pages4
JournalChemistry and Biology
Volume2
Issue number6
DOIs
StatePublished - Jun 1995

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