TY - JOUR
T1 - Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia
T2 - A case report and review of the literature
AU - Porragas-Paseiro, Hector S.
AU - Johnson, Steven
AU - Brubaker, Lindsay
AU - Sanders, Brooke E.
N1 - Publisher Copyright:
© 2023
PY - 2023/12
Y1 - 2023/12
N2 - Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered, and ultimately completed consolidation treatment for GTN on single agent MTX. While MTX administration is associated with an increased risk of PJP, this association is best described in rheumatology literature. This is the first case of PJP complicating MTX therapy within the gynecologic oncology literature.
AB - Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered, and ultimately completed consolidation treatment for GTN on single agent MTX. While MTX administration is associated with an increased risk of PJP, this association is best described in rheumatology literature. This is the first case of PJP complicating MTX therapy within the gynecologic oncology literature.
KW - Gestational trophoblastic neoplasia
KW - Methotrexate
KW - Pneumocystis Jirovecii Pneumonia
UR - http://www.scopus.com/inward/record.url?scp=85173942777&partnerID=8YFLogxK
U2 - 10.1016/j.gore.2023.101286
DO - 10.1016/j.gore.2023.101286
M3 - Article
AN - SCOPUS:85173942777
SN - 2352-5789
VL - 50
JO - Gynecologic Oncology Reports
JF - Gynecologic Oncology Reports
M1 - 101286
ER -