Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome

Andrew P. Groves, Patrick Reich, Binayak Sigdel, T. Keefe Davis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Pneumococcal-associated hemolytic uremic syndrome (pHUS) is a rare but severe complication of invasive Streptococcus pneumoniae infection. We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with adrenocorticotrophic hormone (H.P. Acthar Gel), who developed pneumococcal pneumonia and subsequent pHUS. While nephrotic syndrome is a well-known risk factor for invasive pneumococcal disease, this is the first reported case of pHUS in an adolescent patient with nephrotic syndrome, and reveals novel challenges in the diagnosis, treatment and potential prevention of this complication.

Original languageEnglish
Pages (from-to)572-575
Number of pages4
JournalClinical Kidney Journal
Issue number4
StatePublished - Aug 2016


  • Acthar
  • Hemolytic
  • Nephrotic
  • Streptococcus
  • Uremic


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