PMMA Bone Cement in Interventional Oncology

J. Garnon, L. Meylheuc, J. Jennings, G. Koch, R. Cazzato, B. Bayle, A. Gangi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Polymethylmethacrylate (PMMA) bone cement is increasingly being used for percutaneous minimally invasive treatments of patients suffering from bone malignancies. PMMA is composed of a polymeric powder and a monomeric liquid. Once mixed, the polymerization process begins and leads to a viscous fluid that can be injected through a bone trocar. Cement progressively hardens within the bone, leading to a viscoelastic solid material. PMMA interacts with the surrounding cancellous bone through mechanical interlocking via interdigitations in trabecular bone. It can also bond with hardware, such as titanium screws, as it penetrates the macro-and micro-irregularities of the hardware. PMMA itself has no antineoplastic effects but may be used as a stand-alone treatment to provide pain palliation and bone consolidation through mechanical reinforcement, notably in areas with high compression load. It can also be used to reinforce the anchorage of screws in case of a landing zone with poor bone quality due to underlying malignant osteolysis.

Original languageEnglish
Pages (from-to)35-50
Number of pages16
JournalCritical Reviews in Biomedical Engineering
Volume49
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Bone consolidation
  • Bone–cement interface
  • Pain management
  • Screw anchorage
  • Viscosity

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