TY - JOUR
T1 - Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity
T2 - The HERITAGE family study
AU - Feitosa, Mary F.
AU - Rice, Treva
AU - North, Kari E.
AU - Kraja, Aldi
AU - Rankinen, Tuomo
AU - Leon, Arthur S.
AU - Skinner, James S.
AU - Blangero, John
AU - Bouchard, Claude
AU - Rao, D. C.
N1 - Funding Information:
The HERITAGE Family Study is supported by the National Heart, Lung, and Blood Institute through the following grants: HL45670 (C. Bouchard, PI), HL47323 (A.S. Leon, PI), HL47317 (D.C. Rao, PI) and HL47327 (J.S. Skinner, PI). It is also supported by a NIH grant to the University of Minnesota Clinical Research Center. A.S. Leon is supported in part by the Henry L. Taylor Professorship in Exercise Science and Health Enhancement. C. Bouchard is partially supported by the George A. Bray Chair in Nutrition. Gratitude is expressed to Dr. Jack Wilmore for his numerous contributions to the HERITAGE Family Study.
PY - 2006/4
Y1 - 2006/4
N2 - Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.
AB - Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.
KW - Exercise
KW - Genetic epidemiology
KW - Lipids obesity
KW - Quantitative trait loci
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=33644525258&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2005.06.023
DO - 10.1016/j.atherosclerosis.2005.06.023
M3 - Article
C2 - 16046215
AN - SCOPUS:33644525258
SN - 0021-9150
VL - 185
SP - 426
EP - 432
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -