Pleiotropic effect of LRRK2 on Parkinson-associated proteins and processing of pathological alpha-synuclein in myeloid cells

Keyphrases

• Myeloid Cells 100%
• Alpha-synuclein (α-syn) 100%
• Pleiotropic Effects 100%
• Associated Proteins 100%
• Parkinson 100%
• Leucine-rich Repeat Kinase 2 (LRRK2) 100%
• Cathepsin B 41%
• GPNMB 35%
• CD39 29%
• Cerebrospinal Fluid 23%
• Fluid Level 17%
• Parkinson's Progression Markers Initiative 17%
• Single nucleotide Polymorphism 11%
• Overexpressing 11%
• Parkinson's Disease 11%
• Phosphorylation 5%
• Overexpression 5%
• Protein Level 5%
• Macrophages 5%
• Genome-wide Association Study 5%
• Background mutations 5%
• Human Brain 5%
• Lysosome 5%
• Lentivirus 5%
• Glycoprotein 5%
• Activity Level 5%
• Idiopathic Parkinson's Disease 5%
• Disease-associated 5%
• Western Blotting 5%
• Expression Level 5%
• Pharmacological Inhibitors 5%
• Immunoprecipitates 5%
• Kinase Inhibition 5%
• Kinase Activity 5%
• Genetic Modifiers 5%
• Inflammatory Diseases 5%
• Proteostasis 5%
• Non-carriers 5%
• Cellular Models 5%
• Intracellular Level 5%
• Associated Risk 5%
• Preformed Fibrils 5%
• Lysosomal Proteins 5%
• G2019S 5%
• Disease-related Proteins 5%
• Granulin 5%
• Rab10 5%
• Cohort Data 5%
• In Vitro Data 5%
• Functional Validation 5%
• LAMP1 5%
• U937 5%
• Pleotropic Effects 5%
• SomaLogic 5%
• Autosomal Recessive Parkinsonism 5%
• Nucleoside Triphosphate Diphosphohydrolase 5%
• Human Monocytic Cells 5%
• Human α-synuclein 5%
• Processing Patterns 5%
• R1441C 5%
• M6PR 5%
• Saposin D 5%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Pleiotropy 100%
• Myeloid 100%
• Leucine-Rich Repeat 100%
• Alpha-Synuclein 100%
• Cathepsin B 36%
• GPNMB 31%
• Cerebrospinal Fluid Level 15%
• Single-Nucleotide Polymorphism 10%
• Genetics 5%
• Genome-Wide Association Study 5%
• Autosomal Dominant Inheritance 5%
• Liquid 5%
• Lysosome 5%
• Glycoprotein 5%
• Macrophage 5%
• Western Blot 5%
• Immunoprecipitation 5%
• Protein Homeostasis 5%
• Lentivirus 5%
• LAMP1 5%
• Granulin 5%

Neuroscience

• Myeloid 100%
• Alpha-Synuclein 100%
• Leucine Rich Repeat Kinase 2 100%
• Cathepsin B 41%
• Parkinson's Disease 17%
• Kinase 11%
• Single-Nucleotide Polymorphism 11%
• In Vivo 5%
• In Vitro 5%
• Western Blot 5%
• Macrophage 5%
• Glycoprotein 5%
• Lysosome 5%
• Genome-Wide Association Study 5%
• Immunoprecipitation 5%
• ELISA 5%
• Granulin 5%
• Parkinson Disease Associated Protein 5%
• Sphingolipid Activator Protein 5%