Platelet Tritiated Imipramine Binding and Serotonin Uptake in Depressed Patients and Controls: Relationship to Plasma Cortisol Levels Before and After Dexamethasone Administration

Alec Roy, Don Everett, David Pickar, Steven M. Paul

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

We measured platelet tritiated imipramine binding and serotonin uptake in 51 depressed patients and 43 normal controls. Although there were no significant differences in platelet 3H-imipramine binding or serotonin uptake when the total group of depressed patients was compared with controls, depressed women (n = 32) had a significantly lower maximal density of 3H-imipramine binding sites (βmax) than control women (n = 25). Moreover, among the total group of depressed patients, there were significant negative correlations between the βmaxvalues and plasma cortisol levels at 4 PM (n = 41) and 11 PM (n = 41) following dexamethasone administration. These negative correlations between βmaxand cortisol levels were strongest among melancholic patients both at 4 PM before dexamethasone administration (n =14) and at 11 PM after dexamethasone administration (n =15). These data suggest that the reported decrease in βmaxfound among depressed patients may be related to and is perhaps secondary to the hypercortisolemia of depression.

Original languageEnglish
Pages (from-to)320-327
Number of pages8
JournalArchives of General Psychiatry
Volume44
Issue number4
DOIs
StatePublished - Apr 1987

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