TY - JOUR
T1 - Platelet serotonergic markers and tridimensional personality questionnaire measures in a clinical sample
AU - Nelson, Elliot C.
AU - Cloninger, C. Robert
AU - Przybeck, Thomas R.
AU - Csernansky, John G.
N1 - Funding Information:
Funding for this project was provided by the Bristol-Myers Squibb Company, Wallingford, CT.
PY - 1996/8/15
Y1 - 1996/8/15
N2 - A group of patients with major depressive disorder, with and without comorbid obsessive compulsive disorder, completed the Tridimensional Personality Questionnaire (TPQ). Harm Avoidance scores were found to be high compared to published age-matched norms and to display a significant positive correlation with Hamilton Depression Rating Scale scores. Platelet 125I-lysergic acid diethylamide (125I-LSD) and 3H-paroxetine binding B(max) values were measured to test Cloninger's hypothesis that Harm Avoidance scores would correlate significantly with measures of serotonergic function. A significant inverse correlation was found between Harm Avoidance scores and 125I-LSD B(max) values. Correlations between 3H-paroxetine B(max) values and TPQ scale scores were not significant. These results suggest an alternative view of the literature relating platelet 5-hydroxytryptamine-2a receptors and mood disorders in that the temperament dimension, Harm Avoidance, may explain prior inconsistencies involving links with depression and suicidality.
AB - A group of patients with major depressive disorder, with and without comorbid obsessive compulsive disorder, completed the Tridimensional Personality Questionnaire (TPQ). Harm Avoidance scores were found to be high compared to published age-matched norms and to display a significant positive correlation with Hamilton Depression Rating Scale scores. Platelet 125I-lysergic acid diethylamide (125I-LSD) and 3H-paroxetine binding B(max) values were measured to test Cloninger's hypothesis that Harm Avoidance scores would correlate significantly with measures of serotonergic function. A significant inverse correlation was found between Harm Avoidance scores and 125I-LSD B(max) values. Correlations between 3H-paroxetine B(max) values and TPQ scale scores were not significant. These results suggest an alternative view of the literature relating platelet 5-hydroxytryptamine-2a receptors and mood disorders in that the temperament dimension, Harm Avoidance, may explain prior inconsistencies involving links with depression and suicidality.
KW - Biological markers
KW - Major depressive disorder
KW - Obsessive-compulsive disorder
KW - Paroxetine binding
KW - Personality inventories
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0030586917&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(95)00381-9
DO - 10.1016/0006-3223(95)00381-9
M3 - Article
C2 - 8871773
AN - SCOPUS:0030586917
SN - 0006-3223
VL - 40
SP - 271
EP - 278
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 4
ER -