Platelets primarily mediate hemostasis and thrombosis, whereas leukocytes are responsible for immune responses. Since platelets interact with leukocytes at the site of vascular injury, thrombosis and vascular inflammation are closely intertwined and occur consecutively. Recent studies using real-time imaging technology demonstrated that platelet-neutrophil interactions on the activated endothelium are an important determinant of microvascular occlusion during thromboinflammatory disease in which inflammation is coupled to thrombosis. Although the major receptors and counter receptors have been identified, it remains poorly understood how heterotypic platelet-neutrophil interactions are regulated under disease conditions. This review discusses our current understanding of the regulatory mechanisms of platelet-neutrophil interactions in thromboinflammatory disease.

Original languageEnglish
Pages (from-to)2627-2643
Number of pages17
JournalCellular and Molecular Life Sciences
Issue number14
StatePublished - Jul 24 2015


  • Cell-cell interactions
  • Intracellular signaling
  • Ischemic stroke
  • Regulatory mechanisms
  • Sickle cell disease
  • Surface receptors
  • Vascular disease


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