Platelet aggregometry is a qualitative laboratory study that documents the ability of platelets to aggregate when stimulated by a series of known platelet agonists. The assay has a well-established role in the diagnosis of congenital and acquired platelet function disorders. However, the wide spread incorporation of platelet aggregometry into acute clinical care has been limited by preanalytical variables, lengthy assay times, variations in assay protocol, and by limited clinical trial data to support its usefulness. The aim of this chapter is to describe the methodology of platelet aggregometry, to discuss the clinical interpretation of assay results, and to introduce the potential role it may play in the acute management of trauma patients.
- Platelet aggregation