TY - JOUR
T1 - Platelet activation and secretion in patients with major depression, thoracic aortic atherosclerosis, or renal dialysis treatment
AU - Musselman, Dominique L.
AU - Marzec, Ulla
AU - Davidoff, Madalyn
AU - Manatunga, Amita K.
AU - Gao, Feng
AU - Reemsnyder, Andrea
AU - Duggirala, Sasikanth
AU - Larsen, Hannah
AU - Taylor, Robert W.
AU - Hanson, Stephen
AU - Nemeroff, Charles B.
PY - 2002
Y1 - 2002
N2 - Relatively little is known concerning the magnitude of alterations of platelet activation and secretion markers of patients with major depression when compared to patients at increased risk for, or with current, clinically significant atherosclerosis. Markers of in vivo platelet stimulation and secretion were measured under basal conditions in normal comparison subjects (n = 12) and three patient groups: patients diagnosed with DSM-IV major depression (n = 15), dialysis-dependent patients (n = 12), and patients with severe thoracic aortic atherosclerosis (n = 10). In comparison to normal comparison subjects, depressed patients and patients with thoracic aortic atherosclerosis exhibited the greatest platelet stimulation as detected by increased anti-LIBS platelet binding. Dialysis-dependent patients exhibited the highest plasma concentrations of the renally-excreted platelet-specific secretion protein, β-thromboglobulin. This study extends previous observations of increased platelet activation in patients with major depression and documents similar alterations in patients with transesophageal echocardiography (TEE)-documented thoracic aortic atherosclerosis. Future studies will determine whether the magnitude of platelet stimulation and secretion in patients with comorbid depression and atherosclerotic aortic disease is greater than that observed in nondepressed patients with atherosclerotic aortic disease or major depression alone. These find ings provide further evidence for either increased platelet activation and/or intrinsic heightened platelet reactivity as one of the biological substrates underlying the increased risk of depressed patients for cardiovascular disease.
AB - Relatively little is known concerning the magnitude of alterations of platelet activation and secretion markers of patients with major depression when compared to patients at increased risk for, or with current, clinically significant atherosclerosis. Markers of in vivo platelet stimulation and secretion were measured under basal conditions in normal comparison subjects (n = 12) and three patient groups: patients diagnosed with DSM-IV major depression (n = 15), dialysis-dependent patients (n = 12), and patients with severe thoracic aortic atherosclerosis (n = 10). In comparison to normal comparison subjects, depressed patients and patients with thoracic aortic atherosclerosis exhibited the greatest platelet stimulation as detected by increased anti-LIBS platelet binding. Dialysis-dependent patients exhibited the highest plasma concentrations of the renally-excreted platelet-specific secretion protein, β-thromboglobulin. This study extends previous observations of increased platelet activation in patients with major depression and documents similar alterations in patients with transesophageal echocardiography (TEE)-documented thoracic aortic atherosclerosis. Future studies will determine whether the magnitude of platelet stimulation and secretion in patients with comorbid depression and atherosclerotic aortic disease is greater than that observed in nondepressed patients with atherosclerotic aortic disease or major depression alone. These find ings provide further evidence for either increased platelet activation and/or intrinsic heightened platelet reactivity as one of the biological substrates underlying the increased risk of depressed patients for cardiovascular disease.
KW - Aortic atherosclerosis
KW - Beta-thromboglobulin
KW - Depression
KW - Dialysis
KW - GPIIb/IIIa
KW - Platelet factor 4
KW - Platelet glycoprotein
KW - Platelet secretion
UR - http://www.scopus.com/inward/record.url?scp=0036091808&partnerID=8YFLogxK
U2 - 10.1002/da.10020
DO - 10.1002/da.10020
M3 - Article
C2 - 12001177
AN - SCOPUS:0036091808
SN - 1091-4269
VL - 15
SP - 91
EP - 101
JO - Depression and Anxiety
JF - Depression and Anxiety
IS - 3
ER -