Platelet activating factor synthesis and metabolism in intestinal ischaemia–reperfusion injury

M. J. Mangino, M. Murphy, A. Bohrer, J. Turk, M. J. Mangino, M. Murphy, A. Bohrer, J. Turk

Research output: Contribution to journalArticle

Abstract

The object of this study was to characterize the synthesis and metabolism of platelet activating factor (PAF) by intestinal mucosa subjected to ischaemia-reperfusion injury. Canine intestinal mucosa produced 16:0-PAF, 18:0-PAF, and high levels of the corresponding lyso- PAF metabolites. Three h of intestinal ischaemia and ischaemia followed by 1 h of reperfusion did not affect the synthesis or metabolism of PAF by intestinal mucosa. Intestinal mucosa elaborated a factor that rapidly hydrolyzes PAF to lyso-PAF. The observed hydrolysis rate was not altered by ischaemia or ischaemia and reperfusion. In conclusion, this study suggests that intestinal mucosa produces PAF and rapidly hydrolyzes PAF. The PAF synthesis and metabolism rates of intestinal mucosa is not altered by ischaemia reperfusion in this model under the imposed conditions.

Original languageEnglish
Pages (from-to)393-395
Number of pages3
JournalMediators of Inflammation
Volume3
Issue number5
DOIs
StatePublished - Jan 1 1994

Keywords

  • Canine
  • Ischaemia
  • Lipid mediators
  • Mucosal damage

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    Mangino, M. J., Murphy, M., Bohrer, A., Turk, J., Mangino, M. J., Murphy, M., Bohrer, A., & Turk, J. (1994). Platelet activating factor synthesis and metabolism in intestinal ischaemia–reperfusion injury. Mediators of Inflammation, 3(5), 393-395. https://doi.org/10.1155/S0962935194000554