Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Sara E. Howden; Sean B. Wilson; Ella Groenewegen; Lakshi Starks; Thomas A. Forbes; Ker Sin Tan; Jessica M. Vanslambrouck; Emily M. Holloway; Yi Hsien Chen; Sanjay Jain; Jason R. Spence; Melissa H. Little

doi:10.1016/j.stem.2020.12.001

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Sara E. Howden
, Sean B. Wilson
, Ella Groenewegen
, Lakshi Starks
, Thomas A. Forbes
, Ker Sin Tan
, Jessica M. Vanslambrouck
, Emily M. Holloway
, Yi Hsien Chen
, Sanjay Jain
, Jason R. Spence
, Melissa H. Little

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Little and colleagues demonstrate the plasticity of the distal nephron epithelium present within kidney organoids, showing that this can be induced to adopt a ureteric epithelial phenotype. Subsequent maturation of this epithelium generated collecting ducts, facilitating the accurate modeling of autosomal recessive polycystic kidney disease.

Original language	English
Pages (from-to)	671-684.e6
Journal	Cell Stem Cell
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2020.12.001
State	Published - Apr 1 2021

Keywords

directed differentiation
disease modelling
distal tubule
kidney development
kidney organoid
pluripotent stem cell
polycystic kidney disease
transcriptome profiling
ureteric epithelium
ureteric tip

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10.1016/j.stem.2020.12.001

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Howden, S. E., Wilson, S. B., Groenewegen, E., Starks, L., Forbes, T. A., Tan, K. S., Vanslambrouck, J. M., Holloway, E. M., Chen, Y. H., Jain, S., Spence, J. R., & Little, M. H. (2021). Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk. Cell Stem Cell, 28(4), 671-684.e6. https://doi.org/10.1016/j.stem.2020.12.001

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title = "Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk",

abstract = "Little and colleagues demonstrate the plasticity of the distal nephron epithelium present within kidney organoids, showing that this can be induced to adopt a ureteric epithelial phenotype. Subsequent maturation of this epithelium generated collecting ducts, facilitating the accurate modeling of autosomal recessive polycystic kidney disease.",

keywords = "directed differentiation, disease modelling, distal tubule, kidney development, kidney organoid, pluripotent stem cell, polycystic kidney disease, transcriptome profiling, ureteric epithelium, ureteric tip",

author = "Howden, \{Sara E.\} and Wilson, \{Sean B.\} and Ella Groenewegen and Lakshi Starks and Forbes, \{Thomas A.\} and Tan, \{Ker Sin\} and Vanslambrouck, \{Jessica M.\} and Holloway, \{Emily M.\} and Chen, \{Yi Hsien\} and Sanjay Jain and Spence, \{Jason R.\} and Little, \{Melissa H.\}",

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doi = "10.1016/j.stem.2020.12.001",

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AU - Howden, Sara E.

AU - Wilson, Sean B.

AU - Groenewegen, Ella

AU - Starks, Lakshi

AU - Forbes, Thomas A.

AU - Tan, Ker Sin

AU - Vanslambrouck, Jessica M.

AU - Holloway, Emily M.

AU - Chen, Yi Hsien

AU - Jain, Sanjay

AU - Spence, Jason R.

AU - Little, Melissa H.

PY - 2021/4/1

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KW - directed differentiation

KW - disease modelling

KW - distal tubule

KW - kidney development

KW - kidney organoid

KW - pluripotent stem cell

KW - polycystic kidney disease

KW - transcriptome profiling

KW - ureteric epithelium

KW - ureteric tip

UR - https://www.scopus.com/pages/publications/85099690761

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JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

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Keywords

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