Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Sara E. Howden, Sean B. Wilson, Ella Groenewegen, Lakshi Starks, Thomas A. Forbes, Ker Sin Tan, Jessica M. Vanslambrouck, Emily M. Holloway, Yi Hsien Chen, Sanjay Jain, Jason R. Spence, Melissa H. Little

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Little and colleagues demonstrate the plasticity of the distal nephron epithelium present within kidney organoids, showing that this can be induced to adopt a ureteric epithelial phenotype. Subsequent maturation of this epithelium generated collecting ducts, facilitating the accurate modeling of autosomal recessive polycystic kidney disease.

Original languageEnglish
Pages (from-to)671-684.e6
JournalCell Stem Cell
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2021

Keywords

  • directed differentiation
  • disease modelling
  • distal tubule
  • kidney development
  • kidney organoid
  • pluripotent stem cell
  • polycystic kidney disease
  • transcriptome profiling
  • ureteric epithelium
  • ureteric tip

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