Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Sara E. Howden; Sean B. Wilson; Ella Groenewegen; Lakshi Starks; Thomas A. Forbes; Ker Sin Tan; Jessica M. Vanslambrouck; Emily M. Holloway; Yi Hsien Chen; Sanjay Jain; Jason R. Spence; Melissa H. Little

doi:10.1016/j.stem.2020.12.001

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

Sara E. Howden, Sean B. Wilson, Ella Groenewegen, Lakshi Starks, Thomas A. Forbes, Ker Sin Tan, Jessica M. Vanslambrouck, Emily M. Holloway, Yi Hsien Chen, Sanjay Jain, Jason R. Spence, Melissa H. Little

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68 Scopus citations

Abstract

Little and colleagues demonstrate the plasticity of the distal nephron epithelium present within kidney organoids, showing that this can be induced to adopt a ureteric epithelial phenotype. Subsequent maturation of this epithelium generated collecting ducts, facilitating the accurate modeling of autosomal recessive polycystic kidney disease.

Original language	English
Pages (from-to)	671-684.e6
Journal	Cell Stem Cell
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2020.12.001
State	Published - Apr 1 2021

Keywords

directed differentiation
disease modelling
distal tubule
kidney development
kidney organoid
pluripotent stem cell
polycystic kidney disease
transcriptome profiling
ureteric epithelium
ureteric tip

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10.1016/j.stem.2020.12.001

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Howden, S. E., Wilson, S. B., Groenewegen, E., Starks, L., Forbes, T. A., Tan, K. S., Vanslambrouck, J. M., Holloway, E. M., Chen, Y. H., Jain, S., Spence, J. R., & Little, M. H. (2021). Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk. Cell Stem Cell, 28(4), 671-684.e6. https://doi.org/10.1016/j.stem.2020.12.001

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abstract = "Little and colleagues demonstrate the plasticity of the distal nephron epithelium present within kidney organoids, showing that this can be induced to adopt a ureteric epithelial phenotype. Subsequent maturation of this epithelium generated collecting ducts, facilitating the accurate modeling of autosomal recessive polycystic kidney disease.",

keywords = "directed differentiation, disease modelling, distal tubule, kidney development, kidney organoid, pluripotent stem cell, polycystic kidney disease, transcriptome profiling, ureteric epithelium, ureteric tip",

author = "Howden, {Sara E.} and Wilson, {Sean B.} and Ella Groenewegen and Lakshi Starks and Forbes, {Thomas A.} and Tan, {Ker Sin} and Vanslambrouck, {Jessica M.} and Holloway, {Emily M.} and Chen, {Yi Hsien} and Sanjay Jain and Spence, {Jason R.} and Little, {Melissa H.}",

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AU - Howden, Sara E.

AU - Wilson, Sean B.

AU - Groenewegen, Ella

AU - Starks, Lakshi

AU - Forbes, Thomas A.

AU - Tan, Ker Sin

AU - Vanslambrouck, Jessica M.

AU - Holloway, Emily M.

AU - Chen, Yi Hsien

AU - Jain, Sanjay

AU - Spence, Jason R.

AU - Little, Melissa H.

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KW - disease modelling

KW - distal tubule

KW - kidney development

KW - kidney organoid

KW - pluripotent stem cell

KW - polycystic kidney disease

KW - transcriptome profiling

KW - ureteric epithelium

KW - ureteric tip

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Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

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Keywords

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