Plasmodium eIF2α Kinases

Daniel E. Goldberg, Min Zhang, Victor Nussenzweig

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


eIF2α kinases are stress sensors that respond to external stimuli by phosphorylating the eukaryotic initiation factor eIF2α. This response downregulates cellular protein synthesis but induces the translation of select mRNAs to allow stress survival. In Plasmodium, there are three eIF2α kinases: PfeIK1 responds to amino acid deprivation, while the other two are involved in controlling parasite development. Of the latter kinases, PfPK4 is essential for intraerythrocytic survival, while PfeIK2 controls salivary gland sporozoite latency. The study of parasite eIF2α kinases is broadening the present view of the role of these kinases in cellular and organismal function.

Original languageEnglish
Title of host publicationProtein Phosphorylation in Parasites
Subtitle of host publicationNovel Targets for Antiparasitic Intervention
Number of pages8
ISBN (Electronic)9783527675401
ISBN (Print)9783527332359
StatePublished - Oct 11 2013


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