Plasmacytoid dendritic cells - Virus experts of innate immunity

Winfried Barchet, Marina Cella, Marco Colonna

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

Plasmacytoid dendritic cells (pDC) have emerged as a principal subset of dendritic cells in both human and mouse. PDC morphology, surface markers, their migration in vivo and the ability to rapidly produce large amounts of type I interferons (IFN-α/β) in response to toll like receptor (TLR) triggering sets them apart from other dendritic cell subsets. This review highlights the features that make pDC uniquely able to sense and respond to viral infection.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalSeminars in immunology
Volume17
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • Interferon
  • Interferon-producing cell
  • Plasmacytoid dendritic cell
  • Toll-like receptor
  • Virus

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