TY - JOUR
T1 - Plasmacytoid dendritic cells
T2 - One-trick ponies or workhorses of the immune system?
AU - Reizis, Boris
AU - Colonna, Marco
AU - Trinchieri, Giorgio
AU - Barrat, Franck
AU - Gilliet, Michel
N1 - Funding Information:
We would like to thank our sources of funding for this work. M.M.D. is supported by the Howard Hughes Medical Institute, the Bill and Melinda Gates Foundation (51731) and grants from the US National Institutes of Health (NIH; U19AI057229). J.D.A. is supported by NIH grants to the NIH Tetramer Core Facility (N01A125456M0D13) and the Emory Center for AIDS research (P30 AI050409). E.W.N. is supported by a Steven and Edward Bielfelt Postdoctoral Fellowship from the American Cancer Society.
Funding Information:
M.C. pDCs are inefficient at priming naive CD4+ T cells and, hence, are unlikely to elicit primary CD4+ T cell responses. Given this, it is perhaps not surprising that the antigen processing and presenting machinery of pDCs is quite different from that of cDCs7. Like other MHC class II-expressing cells, however, pDCs can promote the expansion of memory CD4+ T cell populations, thereby facilitating secondary immune responses. pDCs can also contribute to the priming of antigen-specific CD8+ T cells18 and can promote their survival22. pDCs have been implicated in the dif ferentiation of almost every type of CD4+ T cell, including TH1, TH2, TH17, TH22 and regulatory T (TReg) cells6,16. Speculatively, these results may reflect the plasticity of pDCs, which might induce different T cell types depending on their anatomical location, the cytokine microenvironment in which they are immersed and their activation state. This hypothesis is supported by in vitro studies, and by in vivo studies with pDC-depleting antibodies. However, because all available pDC-depleting antibodies are cross-reactive and may deplete additional cell types, it is important to validate pDC plasticity in vivo with alternative
PY - 2011/8
Y1 - 2011/8
N2 - Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?.
AB - Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?.
UR - http://www.scopus.com/inward/record.url?scp=79960835493&partnerID=8YFLogxK
U2 - 10.1038/nri3027
DO - 10.1038/nri3027
M3 - Review article
C2 - 21779033
AN - SCOPUS:79960835493
SN - 1474-1733
VL - 11
SP - 558
EP - 565
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 8
ER -