TY - JOUR
T1 - Plasmacytoid dendritic cells
T2 - In search of their niche in immune responses
AU - Barchet, Winfried
AU - Blasius, Amanda
AU - Cella, Marina
AU - Colonna, Marco
PY - 2005/8/25
Y1 - 2005/8/25
N2 - Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.
AB - Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.
KW - Chemokine
KW - Interferon
KW - Interferon-producing cell
KW - Plasmacytoid dendritic cell
KW - Toll-like receptor
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=23844552372&partnerID=8YFLogxK
M3 - Review article
C2 - 16106060
AN - SCOPUS:23844552372
SN - 0257-277X
VL - 32
SP - 75
EP - 83
JO - Immunologic Research
JF - Immunologic Research
IS - 1-3
ER -