Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate immune system. This review highlights aspects in which pDCs are unique in comparison to other antigen-presenting cells in regulating innate and adaptive immune responses.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalImmunologic Research
Issue number1-3
StatePublished - Aug 25 2005


  • Chemokine
  • Interferon
  • Interferon-producing cell
  • Plasmacytoid dendritic cell
  • Toll-like receptor
  • Virus


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