Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19

Jana L. Jacobs; Asma Naqvi; Faraaz A. Shah; Valerie F. Boltz; Mary F. Kearney; Bryan J. McVerry; Prabir Ray; Caitlin Schaefer; Meghan Fitzpatrick; Barbara Methe; Janet S. Lee; Alison Morris; John W. Mellors; Georgios D. Kitsios; William Bain

doi:10.1093/infdis/jiac157

Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19

Jana L. Jacobs, Asma Naqvi, Faraaz A. Shah, Valerie F. Boltz, Mary F. Kearney, Bryan J. McVerry, Prabir Ray, Caitlin Schaefer, Meghan Fitzpatrick, Barbara Methe, Janet S. Lee, Alison Morris, John W. Mellors, Georgios D. Kitsios, William Bain

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Abstract

Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in serially collected samples from mechanically ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (n = 33, r = 0.83, P < 10-9) and then declined in parallel in available serial samples except in nonsurvivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early after ICU admission.

Original language	English
Pages (from-to)	2089-2094
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	226
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiac157
State	Published - Dec 15 2022

Keywords

COVID-19
RNAemia
SARS-CoV-2
viremia

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Jacobs, J. L., Naqvi, A., Shah, F. A., Boltz, V. F., Kearney, M. F., McVerry, B. J., Ray, P., Schaefer, C., Fitzpatrick, M., Methe, B., Lee, J. S., Morris, A., Mellors, J. W., Kitsios, G. D., & Bain, W. (2022). Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19. Journal of Infectious Diseases, 226(12), 2089-2094. https://doi.org/10.1093/infdis/jiac157

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title = "Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19",

abstract = "Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in serially collected samples from mechanically ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (n = 33, r = 0.83, P < 10-9) and then declined in parallel in available serial samples except in nonsurvivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early after ICU admission.",

keywords = "COVID-19, RNAemia, SARS-CoV-2, viremia",

author = "Jacobs, {Jana L.} and Asma Naqvi and Shah, {Faraaz A.} and Boltz, {Valerie F.} and Kearney, {Mary F.} and McVerry, {Bryan J.} and Prabir Ray and Caitlin Schaefer and Meghan Fitzpatrick and Barbara Methe and Lee, {Janet S.} and Alison Morris and Mellors, {John W.} and Kitsios, {Georgios D.} and William Bain",

note = "Publisher Copyright: {\textcopyright} 2022 Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2022",

month = dec,

day = "15",

doi = "10.1093/infdis/jiac157",

language = "English",

volume = "226",

pages = "2089--2094",

journal = "Journal of Infectious Diseases",

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Jacobs, JL, Naqvi, A, Shah, FA, Boltz, VF, Kearney, MF, McVerry, BJ, Ray, P, Schaefer, C, Fitzpatrick, M, Methe, B, Lee, JS, Morris, A, Mellors, JW, Kitsios, GD & Bain, W 2022, 'Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19', Journal of Infectious Diseases, vol. 226, no. 12, pp. 2089-2094. https://doi.org/10.1093/infdis/jiac157

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T1 - Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19

AU - Jacobs, Jana L.

AU - Naqvi, Asma

AU - Shah, Faraaz A.

AU - Boltz, Valerie F.

AU - Kearney, Mary F.

AU - McVerry, Bryan J.

AU - Ray, Prabir

AU - Schaefer, Caitlin

AU - Fitzpatrick, Meghan

AU - Methe, Barbara

AU - Lee, Janet S.

AU - Morris, Alison

AU - Mellors, John W.

AU - Kitsios, Georgios D.

AU - Bain, William

PY - 2022/12/15

Y1 - 2022/12/15

N2 - Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in serially collected samples from mechanically ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (n = 33, r = 0.83, P < 10-9) and then declined in parallel in available serial samples except in nonsurvivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early after ICU admission.

AB - Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in serially collected samples from mechanically ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (n = 33, r = 0.83, P < 10-9) and then declined in parallel in available serial samples except in nonsurvivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early after ICU admission.

KW - COVID-19

KW - RNAemia

KW - SARS-CoV-2

KW - viremia

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DO - 10.1093/infdis/jiac157

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ER -

Plasma SARS-CoV-2 RNA Levels as a Biomarker of Lower Respiratory Tract SARS-CoV-2 Infection in Critically Ill Patients with COVID-19

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