TY - JOUR
T1 - Plasma palmitate turnover in subjects with thermal injury
AU - Galster, A. D.
AU - Bier, D. M.
AU - Cryer, J. P.
AU - Monafo, William W.
PY - 1984/11
Y1 - 1984/11
N2 - Using a continuous infusion of [1-13C] palmitic acid tracer, plasma palmitate turnover was measured 14 times in nine bandaged, thermally injured adults. Plasma glucose (102 ± 4 mg/dl), insulin (21 ± 4 /µU/ml), and glucagon (296 ± 34 pg/ml) levels were significantly elevated compared with values in uninjured controls. Circulating plasma epinephrine (67 ±11 pg/ml) and norepinephrine (219 ± 57 pg/ml) levels were more than twofold their respective control values of 261 ± 4 pg/ml and 211 ± 7 pg/ml but less than the previously defined plasma threshold levels for lipolytic effects of these catecholamines as circulating hormones. Plasma palmitate and free fatty acid concentrations, 113 ± 8 and 452 ± 38 /µM, respectively, were not different from control values but palmitate flux (2.66 ± 0.28 µmol kg-1min-1) and free fatty acid turnover calculated therefrom (10.53 ± 1.13 µmol kg-1min-1) were significantly elevated compared to the control rates. While palmitate turnover significantly correlated with plasma palmitate concentration and with per cent body surface area burned, there was no relationship between palmitate flux and circulating epinephrine or norepinephrine levels. These data raise new questions about the relative catabolic roles of catecholamines in bandaged, thermally-injured patients.
AB - Using a continuous infusion of [1-13C] palmitic acid tracer, plasma palmitate turnover was measured 14 times in nine bandaged, thermally injured adults. Plasma glucose (102 ± 4 mg/dl), insulin (21 ± 4 /µU/ml), and glucagon (296 ± 34 pg/ml) levels were significantly elevated compared with values in uninjured controls. Circulating plasma epinephrine (67 ±11 pg/ml) and norepinephrine (219 ± 57 pg/ml) levels were more than twofold their respective control values of 261 ± 4 pg/ml and 211 ± 7 pg/ml but less than the previously defined plasma threshold levels for lipolytic effects of these catecholamines as circulating hormones. Plasma palmitate and free fatty acid concentrations, 113 ± 8 and 452 ± 38 /µM, respectively, were not different from control values but palmitate flux (2.66 ± 0.28 µmol kg-1min-1) and free fatty acid turnover calculated therefrom (10.53 ± 1.13 µmol kg-1min-1) were significantly elevated compared to the control rates. While palmitate turnover significantly correlated with plasma palmitate concentration and with per cent body surface area burned, there was no relationship between palmitate flux and circulating epinephrine or norepinephrine levels. These data raise new questions about the relative catabolic roles of catecholamines in bandaged, thermally-injured patients.
UR - http://www.scopus.com/inward/record.url?scp=0021688465&partnerID=8YFLogxK
U2 - 10.1097/00005373-198411000-00003
DO - 10.1097/00005373-198411000-00003
M3 - Article
C2 - 6389897
AN - SCOPUS:0021688465
SN - 0022-5282
VL - 24
SP - 938
EP - 945
JO - Journal of Trauma - Injury, Infection and Critical Care
JF - Journal of Trauma - Injury, Infection and Critical Care
IS - 11
ER -