Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration

Chui Ming Gemmy Cheung, Alfred Gan, Qiao Fan, Miao Ling Chee, Rajendra S. Apte, Chiea Chuen Khor, Ian Yeo, Ranjana Mathur, Ching Yu Cheng, Tien Yin Wong, E. Shyong Tai

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Disturbance in lipid metabolism has been suggested as a major pathogenic factor for age-related macular degeneration (AMD). Conventional lipid measures have been inconsistently associated with AMD. Other factors that can alter lipid metabolism include lipoprotein phenotype and genetic mutations. We performed a case-control study to examine the association between lipoprotein profle and neovascular AMD (nAMD) and whether the cholesterylester transfer protein (CETP) D442G mutation modulates these associations. Patients with nAMD had signifcantly higher concentrations of HDL and IDL compared with controls. The increase in HDL particles in nAMD patients was driven by an excess of medium-sized particles. Concurrently, patients with nAMD also had lower Apo A-1, lower VLDL and chylomicron lipoprotein. Many of these associations showed a dose-dependent association between controls, early AMD cases, and nAMD cases. Adjustment for the presence of the D442G mutation at the CETP locus did not signifcantly alter the increased AMD risk associated with HDL particle concentration. AMD is associated with variation in many lipoprotein subclasses, including increased HDL and IDL particles and decreased Apo A-1, VLDL, and chylomicron particles. These data suggest widespread systemic disturbance in lipid metabolism in the pathogenesis of AMD, including possible alterations in lipoprotein carrier capacity.

Original languageEnglish
Pages (from-to)1785-1796
Number of pages12
JournalJournal of lipid research
Issue number9
StatePublished - 2017


  • Cholesterylester transfer protein
  • Genetics
  • High density lipoprotein


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