Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment

Abdelnaby Khalyfa; Juan F. Masa; Zhuanhong Qiao; Mónica González; Sergi Marti; Ahamed A. Khalyfa; Leila Kheirandish-Gozal; David Gozal

doi:10.1016/j.bbadis.2022.166479

Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment

Abdelnaby Khalyfa
, Juan F. Masa
, Zhuanhong Qiao
, Mónica González
, Sergi Marti
, Ahamed A. Khalyfa
, Leila Kheirandish-Gozal
, David Gozal

Division of Allergy & Pulmonary Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

OHS patients have higher morbidity and mortality rates. Exosomes are released into the bloodstream and play a role in tumor growth and metastasis. Twenty-four OHS patients (13 male and 11 female) were evaluated at diagnosis (Pre), and after CPAP treatment (T3, T12 and T24 months). Plasma exosomes were applied into naïve NCI-H23 lung cancer cells. Exosomes from OHS patients enhance PMI of human lung cancer cells, and these effects are at least partially reversible with adherent CPAP treatment. Our findings suggest that OHS-induced changes in exosome cargo promote cancer aggressiveness in NCI-H23 lung adenocarcinoma and exhibit OHS treatment-related reversibility.

Original language	English
Article number	166479
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1868
Issue number	10
DOIs	https://doi.org/10.1016/j.bbadis.2022.166479
State	Published - Oct 1 2022

Keywords

CPAP
Exosomes
Extracellular vesicles
Intermittent hypoxia
Lung cancer
OHS
OSA

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10.1016/j.bbadis.2022.166479

Cite this

Khalyfa, A., Masa, J. F., Qiao, Z., González, M., Marti, S., Khalyfa, A. A., Kheirandish-Gozal, L., & Gozal, D. (2022). Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1868(10), Article 166479. https://doi.org/10.1016/j.bbadis.2022.166479

@article{d58de70e7ac04da8b925fd10e31e3dcc,

title = "Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment",

abstract = "OHS patients have higher morbidity and mortality rates. Exosomes are released into the bloodstream and play a role in tumor growth and metastasis. Twenty-four OHS patients (13 male and 11 female) were evaluated at diagnosis (Pre), and after CPAP treatment (T3, T12 and T24 months). Plasma exosomes were applied into na{\"i}ve NCI-H23 lung cancer cells. Exosomes from OHS patients enhance PMI of human lung cancer cells, and these effects are at least partially reversible with adherent CPAP treatment. Our findings suggest that OHS-induced changes in exosome cargo promote cancer aggressiveness in NCI-H23 lung adenocarcinoma and exhibit OHS treatment-related reversibility.",

keywords = "CPAP, Exosomes, Extracellular vesicles, Intermittent hypoxia, Lung cancer, OHS, OSA",

author = "Abdelnaby Khalyfa and Masa, \{Juan F.\} and Zhuanhong Qiao and M{\'o}nica Gonz{\'a}lez and Sergi Marti and Khalyfa, \{Ahamed A.\} and Leila Kheirandish-Gozal and David Gozal",

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year = "2022",

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doi = "10.1016/j.bbadis.2022.166479",

language = "English",

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Khalyfa, A, Masa, JF, Qiao, Z, González, M, Marti, S, Khalyfa, AA, Kheirandish-Gozal, L & Gozal, D 2022, 'Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1868, no. 10, 166479. https://doi.org/10.1016/j.bbadis.2022.166479

Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment. / Khalyfa, Abdelnaby; Masa, Juan F.; Qiao, Zhuanhong et al.
In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1868, No. 10, 166479, 01.10.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties

T2 - Effect of long-term adherent CPAP treatment

AU - Khalyfa, Abdelnaby

AU - Masa, Juan F.

AU - Qiao, Zhuanhong

AU - González, Mónica

AU - Marti, Sergi

AU - Khalyfa, Ahamed A.

AU - Kheirandish-Gozal, Leila

AU - Gozal, David

PY - 2022/10/1

Y1 - 2022/10/1

N2 - OHS patients have higher morbidity and mortality rates. Exosomes are released into the bloodstream and play a role in tumor growth and metastasis. Twenty-four OHS patients (13 male and 11 female) were evaluated at diagnosis (Pre), and after CPAP treatment (T3, T12 and T24 months). Plasma exosomes were applied into naïve NCI-H23 lung cancer cells. Exosomes from OHS patients enhance PMI of human lung cancer cells, and these effects are at least partially reversible with adherent CPAP treatment. Our findings suggest that OHS-induced changes in exosome cargo promote cancer aggressiveness in NCI-H23 lung adenocarcinoma and exhibit OHS treatment-related reversibility.

AB - OHS patients have higher morbidity and mortality rates. Exosomes are released into the bloodstream and play a role in tumor growth and metastasis. Twenty-four OHS patients (13 male and 11 female) were evaluated at diagnosis (Pre), and after CPAP treatment (T3, T12 and T24 months). Plasma exosomes were applied into naïve NCI-H23 lung cancer cells. Exosomes from OHS patients enhance PMI of human lung cancer cells, and these effects are at least partially reversible with adherent CPAP treatment. Our findings suggest that OHS-induced changes in exosome cargo promote cancer aggressiveness in NCI-H23 lung adenocarcinoma and exhibit OHS treatment-related reversibility.

KW - CPAP

KW - Exosomes

KW - Extracellular vesicles

KW - Intermittent hypoxia

KW - Lung cancer

KW - OHS

KW - OSA

UR - https://www.scopus.com/pages/publications/85133846087

U2 - 10.1016/j.bbadis.2022.166479

DO - 10.1016/j.bbadis.2022.166479

M3 - Article

C2 - 35811031

AN - SCOPUS:85133846087

SN - 0925-4439

VL - 1868

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 10

M1 - 166479

ER -

Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment

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