Plasma epinephrine and norepinephrine levels during anesthesia: enflurane-N2O-O2 compared with fentanyl-N2O-O2

F. F. Brown, W. D. Owens, J. A. Felts, E. L. Spitznagel, P. E. Cryer

Research output: Contribution to journalArticle

22 Scopus citations


During intra-abdominal surgery, plasma levels of norepinephrine in peripheral venous blood were higher in 11 patients who received fentanyl-nitrous oxide-oxygen than in 10 patients who received enflurane-nitrous oxide-oxygen [703 ± 95 vs 463 ± 38 (SEM) pg/ml]. At the same time, systolic blood pressure (143 ± 6 vs 121 ± 4 torr), mean blood pressure (108 ± 4 vs 98 ± 3 torr and pulse rate (87 ± 3 vs 98 ± 4 beats per minute) also differed significantly (p < 0.05); plasma levels of epinephrine (235 ± 61 vs 113 ± 21) did not. These values did not differ significantly between the two groups before induction of anesthesia, after induction but before skin incision, or in the recovery room. These data support the concept that enflurane anesthesia blocks the sympathetic response to surgical stress more effectively than low dose fentanyl anesthesia.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalAnesthesia and analgesia
Issue number4
StatePublished - Jun 11 1982
Externally publishedYes

Fingerprint Dive into the research topics of 'Plasma epinephrine and norepinephrine levels during anesthesia: enflurane-N<sub>2</sub>O-O<sub>2</sub> compared with fentanyl-N<sub>2</sub>O-O<sub>2</sub>'. Together they form a unique fingerprint.

  • Cite this