TY - JOUR
T1 - Plasma Copper and Metabolic Syndrome in Mesoamerican Children and Their Parents
AU - For the Nine Mesoamerican Countries Metabolic Syndrome (NiMeCoMeS) Study Group
AU - Villatoro-Santos, Claudia R.
AU - Ramirez-Zea, Manuel
AU - Villamor, Eduardo
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/11
Y1 - 2024/11
N2 - The role of copper in the etiology of metabolic syndrome (MetS) is uncertain. We evaluated associations of plasma copper concentrations with MetS and its components in a cross-sectional study of 198 children ages 7–12 years and 378 adult parents from eight Mesoamerican countries. In children, the outcome was a metabolic risk score based on waist circumference, insulin resistance, mean arterial pressure (MAP), and blood lipids. In adults, we defined MetS per Adult Treatment Panel III criteria. Plasma copper was not significantly related to MetS in children or adults; however, children with copper above the median had a MAP score 0.04 (95% CI, 0.002, 0.08; P = 0.04) adjusted units higher and a HDL-cholesterol score 0.07 (95% CI, − 0.13, − 0.003; P = 0.04) adjusted units lower than those with lower copper concentrations. In adults, copper was positively related to abdominal obesity. Longitudinal studies to confirm the deleterious role of copper on MetS components are warranted.
AB - The role of copper in the etiology of metabolic syndrome (MetS) is uncertain. We evaluated associations of plasma copper concentrations with MetS and its components in a cross-sectional study of 198 children ages 7–12 years and 378 adult parents from eight Mesoamerican countries. In children, the outcome was a metabolic risk score based on waist circumference, insulin resistance, mean arterial pressure (MAP), and blood lipids. In adults, we defined MetS per Adult Treatment Panel III criteria. Plasma copper was not significantly related to MetS in children or adults; however, children with copper above the median had a MAP score 0.04 (95% CI, 0.002, 0.08; P = 0.04) adjusted units higher and a HDL-cholesterol score 0.07 (95% CI, − 0.13, − 0.003; P = 0.04) adjusted units lower than those with lower copper concentrations. In adults, copper was positively related to abdominal obesity. Longitudinal studies to confirm the deleterious role of copper on MetS components are warranted.
KW - Blood pressure
KW - Children
KW - Copper
KW - Metabolic syndrome
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85182673347&partnerID=8YFLogxK
U2 - 10.1007/s12011-024-04069-9
DO - 10.1007/s12011-024-04069-9
M3 - Article
C2 - 38240932
AN - SCOPUS:85182673347
SN - 0163-4984
VL - 202
SP - 4903
EP - 4908
JO - Biological Trace Element Research
JF - Biological Trace Element Research
IS - 11
ER -