Plasma concentrations of tumor necrosis factor-α in cats with congestive heart failure

Kathryn M. Meurs, Philip R. Fox, Matthew W. Miller, Samir Kapadia, Douglas L. Mann

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Objective.-To determine whether plasma concentrations of tumor necrosis factor-α (TNF-α) are increased in cats with congestive heart failure (CHF) secondary to cardiomyopathy. Animals.-26 adult cats with CHF and cardiomyopathy and 9 healthy control cats. Procedure.-Plasma concentrations of TNF-α were measured in cats with CHF and cardiomyopathy. Tumor necrosis factor-α was measured by quantifying cytotoxic effects of TNF-α on L929 murine fibrosarcoma cells. Results.-Concentrations of TNF-α were increased (0.13 to 3.6 U/ml) in 10 of 26 cats with CHF but were undetectable in the other 16 cats with CHF and all control cats. In 20 of 26 cats with CHF, right-sided heart failure (RHF) was evident; TNF-α concentrations were increased in 9 of these 20 cats. The remaining 6 cats had left-sided heart failure (LHF); TNF-α concentrations were increased in only 1 of these cats. Age of cats with LHF (mean ± SD, 12.1 ± 6.2 years) was not significantly different from age of the cohort with RHF (10.5 ± 5.2 years). Body weight of cats with increased TNFα concentrations (5.4 ± 1.8 kg) was not significantly different from body weight of cats with CHF that did not have measurable concentrations of TNF-α (4.7 ± 1.6 kg). Conclusions and Clinical Relevance.-Concentrations of TNF-α were increased in many cats with CHF. Cats with RHF were most likely to have increased TNF-α concentrations. Increased plasma concentrations of TNF-α in cats with CHF may offer insights into the pathophysiologic mechanisms of heart failure and provide targets for therapeutic interventions.

Original languageEnglish
Pages (from-to)640-642
Number of pages3
JournalAmerican journal of veterinary research
Volume63
Issue number5
DOIs
StatePublished - Jan 1 2002

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