Plasma atrial natriuretic factor concentrations in a canine model of right heart pressure overload

P. F.G. Cardoso, C. M. Hsieh, L. Daniel, H. Yokomise, H. Kato, B. L. Strangemore, J. D. Miller, A. G. Logan, H. Rakowski, G. A. Patterson, L. M. Blendis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Two studies were carried out in order to evaluate the plasma atrial natriuretic factor (ANF) concentrations, as well as hemodynamic and renal profiles in a chronic canine model of right heart pressure overload induced by pulmonary artery (PA) banding. In study I (n = 6), the animals were submitted to a gradual increase in pressure to clarify whether an increase in pressure or atrial distension was the main stimulus to ANP secretion. In study II (n = 6), right heart pressure overload was produced more rapidly, resulting in fluid retention and weight gain, thereby completing the model of right heart failure, and allowing an evaluation of the mechanisms involved in ANF resistance. In study I there were significant increases in right atrial pressure over baseline at 20 weeks, ANF levels at 24 weeks and right atrial area at 28 weeks following PA banding. In study II right heart pressures and ANF levels were higher than baseline at 12 weeks (p < 0.0001), and fluid retention developed between 12-24 weeks in all dogs. The results suggest that increased right heart pressure, rather than atrial size, is a primary stimulus to ANF secretion in chronic right heart pressure overload. Despite the increases in right atrial pressure, clinical fluid retention occurred only with elevations of renin and aldosterone.

Original languageEnglish
Pages (from-to)310-319
Number of pages10
JournalClinical and Investigative Medicine
Issue number4
StatePublished - Jan 1 1991


  • atrial natriuretic factor
  • hemodynamics
  • renal effects


Dive into the research topics of 'Plasma atrial natriuretic factor concentrations in a canine model of right heart pressure overload'. Together they form a unique fingerprint.

Cite this