Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

Ryan S. Gray; Isabelle Roszko; Lilianna Solnica-Krezel

doi:10.1016/j.devcel.2011.06.011

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

Ryan S. Gray
, Isabelle Roszko
, Lilianna Solnica-Krezel

Research output: Contribution to journal › Review article › peer-review

260 Scopus citations

Abstract

Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.

Original language	English
Pages (from-to)	120-133
Number of pages	14
Journal	Developmental cell
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2011.06.011
State	Published - Jul 19 2011

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title = "Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity",

abstract = "Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.",

author = "Gray, \{Ryan S.\} and Isabelle Roszko and Lilianna Solnica-Krezel",

note = "Funding Information: We would like to thank Drs. Jarema Malicki, Florence Marlow, Diane Sepich, John Wallingford, Yingzi Yang, and Xin Li for critical comments and/or discussion and Linda Lobos for text editing. This work in the Solnica-Krezel laboratory is supported in part by an R01 GM55101 grant from NIH.",

year = "2011",

month = jul,

day = "19",

doi = "10.1016/j.devcel.2011.06.011",

language = "English",

volume = "21",

pages = "120--133",

journal = "Developmental cell",

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T1 - Planar Cell Polarity

T2 - Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

AU - Gray, Ryan S.

AU - Roszko, Isabelle

AU - Solnica-Krezel, Lilianna

N1 - Funding Information: We would like to thank Drs. Jarema Malicki, Florence Marlow, Diane Sepich, John Wallingford, Yingzi Yang, and Xin Li for critical comments and/or discussion and Linda Lobos for text editing. This work in the Solnica-Krezel laboratory is supported in part by an R01 GM55101 grant from NIH.

PY - 2011/7/19

Y1 - 2011/7/19

N2 - Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.

AB - Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.

UR - https://www.scopus.com/pages/publications/79960240783

U2 - 10.1016/j.devcel.2011.06.011

DO - 10.1016/j.devcel.2011.06.011

M3 - Review article

C2 - 21763613

AN - SCOPUS:79960240783

SN - 1534-5807

VL - 21

SP - 120

EP - 133

JO - Developmental cell

JF - Developmental cell

IS - 1

ER -

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

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