TY - JOUR
T1 - Planar Cell Polarity
T2 - Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity
AU - Gray, Ryan S.
AU - Roszko, Isabelle
AU - Solnica-Krezel, Lilianna
N1 - Funding Information:
We would like to thank Drs. Jarema Malicki, Florence Marlow, Diane Sepich, John Wallingford, Yingzi Yang, and Xin Li for critical comments and/or discussion and Linda Lobos for text editing. This work in the Solnica-Krezel laboratory is supported in part by an R01 GM55101 grant from NIH.
PY - 2011/7/19
Y1 - 2011/7/19
N2 - Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.
AB - Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.
UR - http://www.scopus.com/inward/record.url?scp=79960240783&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2011.06.011
DO - 10.1016/j.devcel.2011.06.011
M3 - Review article
C2 - 21763613
AN - SCOPUS:79960240783
SN - 1534-5807
VL - 21
SP - 120
EP - 133
JO - Developmental cell
JF - Developmental cell
IS - 1
ER -