Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

Ryan S. Gray, Isabelle Roszko, Lilianna Solnica-Krezel

Research output: Contribution to journalReview articlepeer-review

219 Scopus citations

Abstract

Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.

Original languageEnglish
Pages (from-to)120-133
Number of pages14
JournalDevelopmental cell
Volume21
Issue number1
DOIs
StatePublished - Jul 19 2011

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