Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling

Mehmet H. Kural, Mingchao Cai, Dalin Tang, Tracy Gwyther, Jie Zheng, Kristen L. Billiar

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Computational models have the potential to provide precise estimates of stresses and strains associated with sites of coronary plaque rupture. However, lack of adequate mathematical description of diseased human vessel wall mechanical properties is hindering computational accuracy. The goal of this study is to characterize the behavior of diseased human coronary and carotid arteries using planar biaxial testing. Diseased coronary specimens exhibit relatively high stiffness (50-210. kPa) and low extensibility (1-10%) at maximum equibiaxial stress (250. kPa) compared to human carotid specimens and values commonly reported for porcine coronary arteries. A thick neointimal layer observed histologically appears to be associated with heightened stiffness and the direction of anisotropy of the specimens. Fung, Choi-Vito and modified Mooney-Rivlin constitutive equations fit the multiaxial data from multiple stress protocols well, and parameters from representative coronary specimens were utilized in a finite element model with fluid-solid interactions. Computed locations of maximal stress and strain are substantially altered, and magnitudes of maximum principal stress (48-65. kPa) and strain (6.5-8%) in the vessel wall are lower than previously predicted using parameters from uniaxial tests. Taken together, the results demonstrate the importance of utilizing disease-matched multiaxial constitutive relationships within patient-specific computational models to accurately predict stress and strain within diseased coronary arteries.

Original languageEnglish
Pages (from-to)790-798
Number of pages9
JournalJournal of Biomechanics
Issue number5
StatePublished - Mar 15 2012


  • Biaxial
  • Carotid
  • Coronary
  • Diseased
  • Human
  • Mechanical stress and strain


Dive into the research topics of 'Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling'. Together they form a unique fingerprint.

Cite this