Pitfalls Associated with the Use of Molecular Diagnostic Panels in the Diagnosis of Cryptococcal Meningitis

Jane A. O'halloran; Alexander Franklin; William Lainhart; Carey Ann Burnham; William Powderly; Erik Dubberke

doi:10.1093/ofid/ofx242

Pitfalls Associated with the Use of Molecular Diagnostic Panels in the Diagnosis of Cryptococcal Meningitis

Jane A. O'halloran
, Alexander Franklin
, William Lainhart
, Carey Ann Burnham
, William Powderly
, Erik Dubberke

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

We report the case of a kidney transplantation patient on chronic immunosuppressive therapy presenting with subacute meningitis. The final diagnosis of cryptococcal meningitis was delayed due to 2 false-negative cryptococcal results on a molecular diagnostic panel. Caution with such platforms in suspected cryptococcal meningitis is needed.

Original language	English
Article number	ofx242
Journal	Open Forum Infectious Diseases
Volume	4
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofx242
State	Published - 2017

Keywords

cryptococcal meningitis
encephalitis
meningitis
molecular diagnostic techniques
polymerase chain reaction

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10.1093/ofid/ofx242

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title = "Pitfalls Associated with the Use of Molecular Diagnostic Panels in the Diagnosis of Cryptococcal Meningitis",

abstract = "We report the case of a kidney transplantation patient on chronic immunosuppressive therapy presenting with subacute meningitis. The final diagnosis of cryptococcal meningitis was delayed due to 2 false-negative cryptococcal results on a molecular diagnostic panel. Caution with such platforms in suspected cryptococcal meningitis is needed.",

keywords = "cryptococcal meningitis, encephalitis, meningitis, molecular diagnostic techniques, polymerase chain reaction",

author = "O'halloran, \{Jane A.\} and Alexander Franklin and William Lainhart and Burnham, \{Carey Ann\} and William Powderly and Erik Dubberke",

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AU - O'halloran, Jane A.

AU - Franklin, Alexander

AU - Lainhart, William

AU - Burnham, Carey Ann

AU - Powderly, William

AU - Dubberke, Erik

PY - 2017

Y1 - 2017

N2 - We report the case of a kidney transplantation patient on chronic immunosuppressive therapy presenting with subacute meningitis. The final diagnosis of cryptococcal meningitis was delayed due to 2 false-negative cryptococcal results on a molecular diagnostic panel. Caution with such platforms in suspected cryptococcal meningitis is needed.

AB - We report the case of a kidney transplantation patient on chronic immunosuppressive therapy presenting with subacute meningitis. The final diagnosis of cryptococcal meningitis was delayed due to 2 false-negative cryptococcal results on a molecular diagnostic panel. Caution with such platforms in suspected cryptococcal meningitis is needed.

KW - cryptococcal meningitis

KW - encephalitis

KW - meningitis

KW - molecular diagnostic techniques

KW - polymerase chain reaction

UR - https://www.scopus.com/pages/publications/85044774451

U2 - 10.1093/ofid/ofx242

DO - 10.1093/ofid/ofx242

M3 - Article

AN - SCOPUS:85044774451

SN - 2328-8957

VL - 4

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 4

M1 - ofx242

ER -

Pitfalls Associated with the Use of Molecular Diagnostic Panels in the Diagnosis of Cryptococcal Meningitis

Abstract

Keywords

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