Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch

Kush N. Patel, Qin Liu, Sonya Meeker, Bradley J. Undem, Xinzhong Dong

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt-/- mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways.

Original languageEnglish
Article numbere20559
JournalPloS one
Volume6
Issue number5
DOIs
StatePublished - 2011

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