Pipeline Embolization of Vertebrobasilar Aneurysms—A Multicenter Case Series

Adam N. Wallace, Thomas P. Madaelil, Mudassar Kamran, Timothy R. Miller, Josser E. Delgado Almandoz, Jonathan A. Grossberg, Akash P. Kansagra, Dheeraj Gandhi, Yasha Kayan, C. Michael Cawley, Christopher J. Moran, Gaurav Jindal, Travis CreveCoeur, Brian M. Howard, De Witte T. Cross, Matthew J. Kole, Anil K. Roy, Jacques E. Dion, Joshua W. Osbun

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: The Pipeline Embolization Device (PED) has been increasingly used for the treatment of posterior circulation aneurysms. The purpose of the present study was to examine the clinical and angiographic outcomes of patients with vertebrobasilar aneurysms treated with the PED. Methods: We performed a retrospective review of vertebrobasilar aneurysms treated with the PED at 4 high-volume neurovascular centers. Patient, aneurysm, and procedural data were collected, including perioperative and delayed complications. Aneurysm occlusion on follow-up imaging studies was defined as complete (100%), near-complete (>90%), or incomplete (<90%) occlusion. Results: The cohort included 35 patients with 37 vertebrobasilar aneurysms who underwent 36 treatment sessions. Of the 35 patients, 10 were men (29%), and the mean patient age was 54.1 years (range, 32–75). Eight patients (23%) underwent urgent treatment because of a ruptured aneurysm (n = 6), brainstem perforator stroke (n = 1), or post-traumatic pseudoaneurysm (n = 1). Of the 37 aneurysms, 22 arose from the vertebral artery (59%) and 15 from the basilar artery (41%). Also, 19 were saccular aneurysms (51%), with a mean size of 7.7 mm (range, 1.7–38.0); 17 were fusiform aneurysms (46%), with a mean size of 11.0 mm (range, 4.3–34); and 1 was a 2.9-mm blister aneurysm. The overall procedural complication rate was 14% (5 of 36), including 3 neurologically symptomatic complications. At a mean follow-up period of 14 months (range, 3–59), 24 of 34 aneurysms (71%) were completely occluded and 29 of 34 (85%) were completely or near-completely occluded. Conclusion: Our results show that Pipeline embolization of vertebrobasilar aneurysms is associated with acceptable occlusion and complication rates.

Original languageEnglish
Pages (from-to)e460-e469
JournalWorld neurosurgery
StatePublished - Apr 2019


  • Aneurysm
  • Pipeline embolization
  • Posterior circulation
  • Vertebrobasilar


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