Noonan syndrome (NS; MIM 163950) is an autosomal dominant dysmorphic syndrome characterized by distinct facial features, cardiac anomalies, short stature, and motor delay. Activating mutations in PTPN11, encoding the protein tyrosine phosphatase SHP2, are associated with about 50% of cases. Mutations in other genes in the RAS/mitogen-activated protein kinase signaling pathway are responsible for many of the remainder of cases. While mutations in this pathway are found in a variety of malignancies, including solid tumors, there are few reports of solid tumors in individuals with NS. We report here a patient with PTPN11 mutation-associated NS and a pilocytic astrocytoma.

Original languageEnglish
Pages (from-to)1147-1149
Number of pages3
JournalPediatric Blood and Cancer
Issue number6
StatePublished - 2009


  • Astrocytoma
  • Noonan syndrome
  • PTPN11


Dive into the research topics of 'Pilocytic astrocytoma in a child with Noonan syndrome'. Together they form a unique fingerprint.

Cite this