Physiopathologie de l'arthrose. Du cartilage normal au cartilage arthrosique: facteurs de prédisposition et mécanismes inflammatoires

Translated title of the contribution: Physiopathology of osteoarthritis. From normal cartilage to osteoarthritic cartilage: susceptibility factors and inflammatory mechanisms

L. Laadhar, M. Zitouni, M. Kalle-Sellami, M. Mahjoub, S. Sellami, S. Makni

Research output: Contribution to journalShort survey

13 Scopus citations

Abstract

Introduction: osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it becomes a major problem of public health. Osteoarthritis is a degenerative affection characterized by many disorders leading to a structural and functional defect of one or several joints. Current knowledge and key points: In this review, we focus on the main inflammatory mechanisms occurring in cartilage during primary osteoarthritis. We also describe some well established risk factors involved in the pathogenesis of this disease such as age, overload and genetic factors. Indeed, osteoarthritis is the result of an imbalance between the processes of degradation and the attempts of repair by the chondrocyte which is the exclusive cell type in cartilage. Degradation is induced by several chemical substances such as proteolytic enzymes (metalloproteinases) and pro-inflammatory cytokines especially interleukin 1β. To face these events, the chondrocyte starts attempts of repair by secreting growth factors (Transforming Growth Factor and Insulin Growth Factor) or anti-inflammatory cytokines (interleukins 4 and 10) unsuccessfully. All these events will lead to the structural modifications observed in the osteoarthritic cartilage. Prospects: A better comprehension of the physiopathology of osteoarthritis will allow an improvement of therapeutic strategies of this common and invalidating disease.

Translated title of the contributionPhysiopathology of osteoarthritis. From normal cartilage to osteoarthritic cartilage: susceptibility factors and inflammatory mechanisms
Original languageFrench
Pages (from-to)531-536
Number of pages6
JournalRevue de Medecine Interne
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Keywords

  • Chondrocyte
  • Cytokines
  • Inflammation
  • Osteoarthritis

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