TY - JOUR
T1 - Physiologic and pathologic effects of dietary free fatty acids on cells of the joint
AU - Harasymowicz, Natalia S.
AU - Dicks, Amanda
AU - Wu, Chia Lung
AU - Guilak, Farshid
N1 - Funding Information:
The authors thank Sara Oswald for providing technical writing support for the manuscript. This study was supported in part by NIH Grants AR50245, AR48852, AG15768, AR48182, AG46927, OD10707, DK108742, EB018266, AR073752, the Washington University Musculoskeletal Research Center (NIH P30 AR057235), the Arthritis Foundation, and the Nancy Taylor Foundation for Chronic Diseases. Author contributions: N.S.H. wrote the initial draft; A.D., C.-L.W., and F.G. contributed additional writing and editing of the manuscript.
Publisher Copyright:
© 2019 New York Academy of Sciences.
PY - 2019/3
Y1 - 2019/3
N2 - Fatty acids (FAs) are potent organic compounds that not only can be used as an energy source during nutrient deprivation but are also involved in several essential signaling cascades in cells. Therefore, a balanced intake of different dietary FAs is critical for the maintenance of cellular functions and tissue homeostasis. A diet with an imbalanced fat composition creates a risk for developing metabolic syndrome and various musculoskeletal diseases, including osteoarthritis (OA). In this review, we summarize the current state of knowledge and mechanistic insights regarding the role of dietary FAs, such as saturated FAs, omega-6 polyunsaturated FAs (PUFAs), and omega-3 PUFAs on joint inflammation and OA pathogeneses. In particular, we review how different types of dietary FAs and their derivatives distinctly affect a variety of cells within the joint, including chondrocytes, osteoblasts, osteoclasts, and synoviocytes. Understanding the molecular mechanisms underlying the effects of FAs on metabolic behavior, anabolic, and catabolic processes, as well as the inflammatory response of joint cells, may help identify therapeutic targets for the prevention of metabolic joint diseases.
AB - Fatty acids (FAs) are potent organic compounds that not only can be used as an energy source during nutrient deprivation but are also involved in several essential signaling cascades in cells. Therefore, a balanced intake of different dietary FAs is critical for the maintenance of cellular functions and tissue homeostasis. A diet with an imbalanced fat composition creates a risk for developing metabolic syndrome and various musculoskeletal diseases, including osteoarthritis (OA). In this review, we summarize the current state of knowledge and mechanistic insights regarding the role of dietary FAs, such as saturated FAs, omega-6 polyunsaturated FAs (PUFAs), and omega-3 PUFAs on joint inflammation and OA pathogeneses. In particular, we review how different types of dietary FAs and their derivatives distinctly affect a variety of cells within the joint, including chondrocytes, osteoblasts, osteoclasts, and synoviocytes. Understanding the molecular mechanisms underlying the effects of FAs on metabolic behavior, anabolic, and catabolic processes, as well as the inflammatory response of joint cells, may help identify therapeutic targets for the prevention of metabolic joint diseases.
KW - arthritis
KW - bone
KW - cartilage
KW - diabetes
KW - obesity
KW - synovium
UR - http://www.scopus.com/inward/record.url?scp=85060124701&partnerID=8YFLogxK
U2 - 10.1111/nyas.13999
DO - 10.1111/nyas.13999
M3 - Review article
C2 - 30648276
AN - SCOPUS:85060124701
SN - 0077-8923
VL - 1440
SP - 36
EP - 53
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -