TY - JOUR
T1 - Physical activity and head and neck cancer risk
AU - Leitzmann, Michael F.
AU - Koebnick, Corinna
AU - Freedman, Neal D.
AU - Park, Yikyung
AU - Ballard-Barbash, Rachel
AU - Hollenbeck, Albert R.
AU - Schatzkin, Arthur
AU - Abnet, Christian C.
N1 - Funding Information:
Acknowledgments We are grateful to the participants in the NIH-AARP Diet and Health Study for their outstanding cooperation. We thank Leslie Carroll at Information Management Services and Sigurd Hermansen and Kerry Grace Morrissey from Westat for data support, and Tawanda Roy at the Nutritional Epidemiology Branch for research assistance. Financial Support: This research was supported by the Intramural Research Program of the NIH, National Cancer Institute.
PY - 2008/12
Y1 - 2008/12
N2 - Objective: To investigate the relation of physical activity to head and neck cancer. Methods: We prospectively examined the association between physical activity and head and neck cancer in 487,732 men and women, who, at baseline in 1995-1996, were 50-71 years old and free of cancer and emphysema. Follow-up occurred through 31 December 2003. Results: During follow-up, 1,249 participants developed head and neck cancer, of which 42.0%, 18.9%, and 32.5% were located in the oral cavity, pharynx, and larynx, respectively. In analyses adjusted for age and gender, the relative risks (RR) of head and neck cancer for increasing frequency of physical activity (0, < 1, 1-2, 3-4, and ≥5 times per week) were 1.0 (reference), 0.76, 0.66, 0.57, and 0.62 (95% CI = 0.52-0.74), respectively (p for trend < 0.001). After multivariate adjustment including smoking, the relation was attenuated and became statistically non-significant (RR comparing extreme physical activity categories = 0.89, 95% CI = 0.74-1.06; p for trend = 0.272). In analyses of head and neck cancer subtypes, the corresponding RRs for cancers of the oral cavity, pharynx, and larynx were 0.98 (95% CI = 0.75-1.29), 0.70 (95% CI = 0.45-1.08), and 0.82 (95% CI = 0.59-1.13), respectively. Conclusions: Our findings suggest that physical activity is unlikely to play an important role in the prevention of head and neck cancer.
AB - Objective: To investigate the relation of physical activity to head and neck cancer. Methods: We prospectively examined the association between physical activity and head and neck cancer in 487,732 men and women, who, at baseline in 1995-1996, were 50-71 years old and free of cancer and emphysema. Follow-up occurred through 31 December 2003. Results: During follow-up, 1,249 participants developed head and neck cancer, of which 42.0%, 18.9%, and 32.5% were located in the oral cavity, pharynx, and larynx, respectively. In analyses adjusted for age and gender, the relative risks (RR) of head and neck cancer for increasing frequency of physical activity (0, < 1, 1-2, 3-4, and ≥5 times per week) were 1.0 (reference), 0.76, 0.66, 0.57, and 0.62 (95% CI = 0.52-0.74), respectively (p for trend < 0.001). After multivariate adjustment including smoking, the relation was attenuated and became statistically non-significant (RR comparing extreme physical activity categories = 0.89, 95% CI = 0.74-1.06; p for trend = 0.272). In analyses of head and neck cancer subtypes, the corresponding RRs for cancers of the oral cavity, pharynx, and larynx were 0.98 (95% CI = 0.75-1.29), 0.70 (95% CI = 0.45-1.08), and 0.82 (95% CI = 0.59-1.13), respectively. Conclusions: Our findings suggest that physical activity is unlikely to play an important role in the prevention of head and neck cancer.
KW - Head and neck cancer
KW - Larynx cancer
KW - Oral cavity cancer
KW - Pharynx cancer
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=55849096958&partnerID=8YFLogxK
U2 - 10.1007/s10552-008-9211-0
DO - 10.1007/s10552-008-9211-0
M3 - Article
C2 - 18704714
AN - SCOPUS:55849096958
SN - 0957-5243
VL - 19
SP - 1391
EP - 1399
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -