TY - JOUR
T1 - Physical Activity and Esophageal and Gastric Carcinoma in a Large Prospective Study
AU - Leitzmann, Michael F.
AU - Koebnick, Corinna
AU - Freedman, Neal D.
AU - Park, Yikyung
AU - Ballard-Barbash, Rachel
AU - Hollenbeck, Albert
AU - Schatzkin, Arthur
AU - Abnet, Christian C.
N1 - Funding Information:
In 1995–1996, AARP (formerly known as the American Association of Retired Persons) members numbering 566,402 aged 50–71 years and residing in one of six U.S. states (CA, FL, LA, NJ, NC, or PA) or in one of two metropolitan areas (Atlanta GA or Detroit MI) completed and returned a mailed questionnaire on medical history, diet history, and physical activity to initiate the NIH–AARP Diet and Health Study. 21 The study was approved by the Special Studies IRB of the U.S. National Cancer Institute.
PY - 2009/2
Y1 - 2009/2
N2 - Background: Few studies have investigated the relationship of physical activity to esophageal and gastric carcinoma according to histology and anatomic site. Methods: This study prospectively investigated the association between physical activity and esophageal and gastric carcinoma in a cohort of 487,732 U.S. men and women, followed from 1995-1996 to December 31, 2003. All analyses were performed in 2007-2008. Results: During 8 years of follow-up study, 523 cases of esophageal carcinoma (149 squamous cell and 374 adenocarcinoma) and 642 cases of gastric carcinoma (313 cardia and 329 noncardia) were documented. Physical activity was associated with reduced risk of esophageal and gastric adenocarcinomas but was unrelated to esophageal squamous cell carcinoma. The inverse association with physical activity was strongest for gastric noncardia adenocarcinoma (multivariate relative risk [RR] for highest versus lowest physical activity level=0.62, 95% CI=0.44, 0.87). Relationships were weaker but evident for gastric cardia adenocarcinoma (RR=0.83; 95% CI=0.58, 1.19) and esophageal adenocarcinoma (RR=0.75; 95% CI=0.53, 1.06). No significant relationship with physical activity was observed for esophageal squamous cell carcinoma (RR=1.05; 95% CI=0.64, 1.74). Exclusion of cases diagnosed during the first 2 follow-up years did not change those estimates, indicating that the findings are not due to decreased activity levels among participants with undiagnosed cancer at entry. Conclusions: Physical activity may play a role in the prevention of upper gastrointestinal tract adenocarcinomas. No association was seen between physical activity and esophageal squamous cell carcinoma.
AB - Background: Few studies have investigated the relationship of physical activity to esophageal and gastric carcinoma according to histology and anatomic site. Methods: This study prospectively investigated the association between physical activity and esophageal and gastric carcinoma in a cohort of 487,732 U.S. men and women, followed from 1995-1996 to December 31, 2003. All analyses were performed in 2007-2008. Results: During 8 years of follow-up study, 523 cases of esophageal carcinoma (149 squamous cell and 374 adenocarcinoma) and 642 cases of gastric carcinoma (313 cardia and 329 noncardia) were documented. Physical activity was associated with reduced risk of esophageal and gastric adenocarcinomas but was unrelated to esophageal squamous cell carcinoma. The inverse association with physical activity was strongest for gastric noncardia adenocarcinoma (multivariate relative risk [RR] for highest versus lowest physical activity level=0.62, 95% CI=0.44, 0.87). Relationships were weaker but evident for gastric cardia adenocarcinoma (RR=0.83; 95% CI=0.58, 1.19) and esophageal adenocarcinoma (RR=0.75; 95% CI=0.53, 1.06). No significant relationship with physical activity was observed for esophageal squamous cell carcinoma (RR=1.05; 95% CI=0.64, 1.74). Exclusion of cases diagnosed during the first 2 follow-up years did not change those estimates, indicating that the findings are not due to decreased activity levels among participants with undiagnosed cancer at entry. Conclusions: Physical activity may play a role in the prevention of upper gastrointestinal tract adenocarcinomas. No association was seen between physical activity and esophageal squamous cell carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=58149289700&partnerID=8YFLogxK
U2 - 10.1016/j.amepre.2008.09.033
DO - 10.1016/j.amepre.2008.09.033
M3 - Article
C2 - 19062237
AN - SCOPUS:58149289700
SN - 0749-3797
VL - 36
SP - 112
EP - 119
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
IS - 2
ER -