Physical activity and benign prostatic hyperplasia-related outcomes and nocturia

Kathleen Y. Wolin, Robert L. Grubb, Ratna Pakpahan, Lawrence Ragard, Jerome Mabie, Gerald L. Andriole, Siobhan Sutcliffe

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Introduction: Benign prostatic hyperplasia (BPH) and its associated lower urinary tract symptoms (LUTS), including nocturia, are extremely common among middle- and older-age American men. Although studies on physical activity (PA) and prevalent BPHrelated outcomes suggest that PA may protect against the development of this common condition, only a few studies have examined the relation between PAand incident BPH-related outcomes and LUTSwithmixed findings. In addition, although nocturia is themost commonly reported and most bothersome LUTS in men with or without evidence of BPH, few studies have examined the association of PA and nocturia independent of BPH. The purpose of this analysis was to examine the association of PA with BPH-related outcomes and nocturia in the Prostate, Lung, Colorectal, andOvarian Cancer Screening trial. Methods:We examined this association with both prevalent (n = 28,404) and incident (n = 4710) BPH-related outcomes (measured by self-report of physician diagnosis, BPH surgery, finasteride use, and clinical indicators) and nocturia. Poisson regression with robust variance was used to calculate prevalence ratios and relative risks. Results: PA was weakly positively associated with several prevalent BPH-related outcomes and was strongly inversely associated with prevalent nocturia. In incident analyses, PA was only associated with nocturia. Men who were active Q1 hIwkj1 were 13% less likely (95% confidence interval, 2%-22%) to report nocturia and 34% less likely (95% confidence interval, 15%-49%) to report severe nocturia as compared with men who reported no PA. The associations were similar for men with and without additional BPH-related outcomes, except for prevalent nocturia, where the association was stronger for men without other BPH-related outcomes. Conclusions: Combined with other management strategies, PA may provide a strategy for the management of BPH-related outcomes, particularly nocturia.

Original languageEnglish
Pages (from-to)581-592
Number of pages12
JournalMedicine and Science in Sports and Exercise
Volume47
Issue number3
DOIs
StatePublished - Mar 26 2014

Keywords

  • Benign prostatic hyperplasia
  • lower urinary tract symptoms
  • nocturia
  • physical activity

Fingerprint

Dive into the research topics of 'Physical activity and benign prostatic hyperplasia-related outcomes and nocturia'. Together they form a unique fingerprint.

Cite this